A new study by neuroscientists at the German Primate Center (DPZ) – Leibniz Institute for Primate Research in Göttingen shows that our brain deals with different forms of visual uncertainty during movements in distinct ways. Depending on the type of uncertainty, planning and execution of movements in the brain are affected differently. These findings could help to optimize brain-computer interfaces that, for example, help people with paralysis to control prostheses or computers with their thoughts alone (Nature Communications). Imagine waking…

Bioinformatics: Publication in Science Bioinformaticians from Heinrich Heine University Düsseldorf (HHU) and the university in Linköping (Sweden) have established that the genes in bacterial genomes are arranged in a meaningful order. In the renowned scientific journal Science, they describe that the genes are arranged by function: If they become increasingly important at faster growth, they are located near the origin of DNA replication. Accordingly, their position influences how their activity changes with the growth rate. Are genes distributed randomly along…

Team from the University of Tübingen and the German Center for Infection Research discovers a substance that inhibits signaling pathways of pathogens as they invade a cell Pathogenic Salmonella injects effector proteins into the cells of the gastrointestinal tract to penetrate and multiply within them. The bacteria are usually ingested with contaminated food. They can cause serious gastrointestinal inflammation and even systemic infections. Now, an international research team led by Professor Samuel Wagner of the University of Tübingen Cluster of…

Light conditions in the morning before waking up affect restfulness Sleep is a necessary part of people’s daily routine, but modern lifestyles and technology have ushered in an era of decreased rest time and subsequent fatigue. Further, the bedroom environment, such as light, sound, and temperature, is important for a good night’s sleep, though this is often neglected in residential architecture. In search of a conclusive remedy, common sleep studies use artificial light that is easy to control. Osaka Metropolitan…

Mechanical compression induces multicellular organization in archaeaIn a discovery that reframes our understanding of life’s fundamental organization, researchers at Brandeis University, the MRC Laboratory of Molecular Biology, and the Max Planck Institute for Biology Tübingen have found that mechanical compression can induce the formation of tissue-like multicellular structures in archaea. This novel finding, focusing on the haloarchaeon Haloferax volcanii, reveals a previously unknown pathway for the emergence of multicellularity within this domain of life, offering new insights into the evolutionary…

Cytochrome P450 (CYP) proteins are responsible for breaking down more than 80% of all Food and Drug Administration (FDA) approved drugs, reducing their effectiveness. However, how to prevent CYPs from doing this without off-target effects has puzzled researchers until now. Scientists at St. Jude Children’s Research Hospital have designed new drug frameworks that selectively target CYP3A4, one of the most critical CYP proteins. Structural insights from this work offer a roadmap for future drug developers to better evaluate drug interactions and selectively…

The research groups led by Wolfgang Kastenmüller and Georg Gasteiger employed innovative microscopy techniques to observe how specific immune cells, known as T-cells, are activated and proliferate during a viral infection. Their findings revealed novel mechanisms: the immune system amplifies its defense cells in a far more targeted way than previously believed. T-Cells Proliferate and Specialize During the Immune Response T-cells are crucial defense cells in the immune system. To effectively find and destroy infected cells in the body, rare…

Capturing carbon dioxide (CO₂) from industrial emissions is crucial in the fight against climate change. But current methods, like chemical absorption, are expensive and energy-intensive. Scientists have long eyed graphene—an atom-thin, ultra-strong material—as a promising alternative for gas separation, but making large-area, efficient graphene membranes has been a challenge. Now, a team at EPFL, led by Professor Kumar Agrawal, has developed a scalable technique to create porous graphene membranes that selectively filter CO₂ from gas mixtures. Their approach slashes production…

A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before. Their technology, ENVLPE, uses engineered non-infectious virus-like particles to precisely correct defective genes – demonstrated successfully in living mouse models that are blind due to a mutation. This system also holds promise for advancing cancer therapy by enabling precise genetic manipulation of engineered…

The development of new antibiotics to treat superbugs and other bacterial infections is a global priority, with the rate of infections that cannot be treated with current antibiotics rising and presenting one of the biggest threats to human health. In line with that, new research has shown a daily dose of epidermicin NI01 – an antibiotic compound developed by University of Plymouth spinout company Amprologix – is as effective at removing Methicillin-resistant Staphylococcus aureus (MRSA) as the current standard of…

Researchers developed a cell-based reporter assay that can quantify epigenetic changes induced by chemicals and potential carcinogens Chemicals used as food preservatives, flavoring agents, dyes, pesticides, cosmetics, cleaners, and other industrial materials are being increasingly recognized as a health hazard. Their rampant use has led to an increase in the prevalence of various chemical toxicity-induced diseases, including hormonal disruption, cancer, neurological disorders, skin conditions, and occupational poisoning. Numerous chemicals are known to trigger “carcinogenesis” or cancer development by exerting genotoxic…

At the RNApp graduate school, young researchers are working to make RNA-based drugs safer and more effective. Ribonucleic acid (RNA) is an important component of our cells. As messenger RNA (mRNA), it is the blueprint for translating genetic information into proteins. This process can also be used medically to produce specific proteins. One well-known application is mRNA vaccines against coronaviruses. There is also so-called non-coding RNA (ncRNA), which does not contain protein blueprints but instead takes over control mechanisms in…

Researchers explore transition metal-free strategies to reduce environmental impact and enhance efficiency in pharmaceutical and fine chemical industries Coupling reactions are among the most transformative tools in organic chemistry, enabling the formation of crucial chemical bonds in pharmaceuticals, agrochemicals, and advanced materials. Since their introduction, they have been one of the backbones of modern organic synthesis. However, these methods have long relied on environmentally taxing transition metal catalysts, such as palladium, which are often scarce, costly, and generate unwanted byproducts….

New Australian technology is set to transform the way that gastrointestinal cancers are detected and treated with precise, minimally invasive surgery. Backed by the Federal Government’s Economic Accelerator (AEA) Ignite Grant, researchers from the University of South Australia (UniSA) are using quantum technology to develop a first-of-its-kind laparoscopic probe that will allow surgeons to accurately map the spread of tumours. The technology has the potential to improve cancer survival rates and patient quality of life worldwide. Led by Dr Nicole…

Medicine: Publication in Science Advances Damage to the mitochondria, the “power plants” of the cells, contributes to many diseases. Researchers from Heinrich Heine University Düsseldorf (HHU) and the University of Cologne led by HHU professor of medicine Dr David Pla-Martín, now describe in the scientific journal Science Advances how cells with defective mitochondria activate a special recycling system to eliminate damaged genetic material. Damage to the genetic material of mitochondria – the mitochondrial DNA or mtDNA for short – can…

Study led by Johns Hopkins researchers may advance efforts to reveal how epigenetic events contribute to cancer development Johns Hopkins Medicine scientists say they have found a pattern of so-called epigenetic “marks” in a transition state between normal and pancreatic cancer cells in mice, and that the normal cells may keep at least a temporary “memory” of those cancer-linked marks. Epigenetic marks are chemical modifications that help regulate genetic expression without directly altering DNA sequence in the makeup of genes….