… is feasible, safe in people. Sonobiopsies generate genetic, molecular data to inform treatment decisions for brain diseases. The blood-brain barrier, the body’s way of shielding sensitive brain tissue from viruses, toxins and other harmful substances in the blood, can pose a problem for physicians caring for patients with suspected brain diseases such as cancer. Molecular and genetic information would be invaluable for confirming a diagnosis and guiding treatment decisions, but such molecules are normally confined to the brain by…
… to improve accuracy of breast cancer tumor removal. Artificial intelligence (AI) and machine learning tools have received a lot of attention recently, with the majority of discussions focusing on proper use. However, this technology has a wide range of practical applications, from predicting natural disasters to addressing racial inequalities and now, assisting in cancer surgery. A new clinical and research partnership between the UNC Department of Surgery, the Joint UNC-NCSU Department of Biomedical Engineering, and the UNC Lineberger Comprehensive…
A collaboration between researchers at the University of Illinois Urbana-Champaign and Duke University has developed a robotic eye examination system, and the National Institutes of Health has awarded the researchers $1.2 million to expand and refine the system. The researchers have developed a robotic system that automatically positions examination sensors to scan human eyes. It currently uses an optical scan technique which can operate from a reasonably safe distance from the eye, and now the researchers are working to add…
Lung cancer is the leading cause of cancer-related deaths in the United States. Some tumors are extremely small and hide deep within lung tissue, making it difficult for surgeons to reach them. To address this challenge, UNC –Chapel Hill and Vanderbilt University researchers have been working on an extremely bendy but sturdy robot capable of traversing lung tissue. Their research has reached a new milestone. In a new paper, published in Science Robotics, Ron Alterovitz, PhD, in the UNC Department…
Chemotherapy as a treatment for cancer is one of the major medical success stories of the 20th century, but it’s far from perfect. Anyone who has been through chemotherapy or who has had a friend or loved one go through it will be familiar with its many side effects: hair loss, nausea, weakened immune system, and even infertility and nerve damage. This is because chemotherapy drugs are toxic. They’re meant to kill cancer cells by poisoning them, but since cancer…
The device contains encapsulated cells that produce insulin, plus a tiny oxygen-producing factory that keeps the cells healthy. One promising approach to treating Type 1 diabetes is implanting pancreatic islet cells that can produce insulin when needed, which can free patients from giving themselves frequent insulin injections. However, one major obstacle to this approach is that once the cells are implanted, they eventually run out of oxygen and stop producing insulin. To overcome that hurdle, MIT engineers have designed a…
Researchers at TU Dresden create pioneering approaches for the detection of viral antigens. The outbreak of the COVID pandemic in 2020 has once again shown how important reliable and rapid detection methods are to initiate effective measures to combat a pandemic. Scientists from the Chair of Materials Science and Nanotechnology at TU Dresden (TUD) have made considerable progress in the development of highly innovative solutions for the detection of viral pathogens in two studies they presented recently. The results of…
The project coordinated by Istituto Italiano di Tecnologia has been funded with 3 million euro by the European Union. A tool that uses light to study biological molecules without interfering with their nanometric structure and that allows scientists to image basic living mechanisms with sub-millisecond acquisition time. It is the new generation microscope Micro4PAP, which is able to perform in-vivo imaging of the cell mechanical properties (rigidity, stiffness, viscosity), which is under development within the EU-funded project Micro4PAP led by…
Scientists combine Bessel beam two-photon microscopy with high throughput analysis for faster and more precise measurements of blood flow. The brain is perhaps the most sensitive organ with respect to changes in blood flow and oxygen supply. Even brief interruptions in capillary flow (or “stalling”) can indicate acute neurological issues; evidence suggests that chronic conditions like Alzheimer’s and Parkinson’s diseases are closely related to stalling events. Thus, investigating the effects of stalling could lead to the development of therapies for…
The EU-funded Human Brain Project (HBP) comes to an end in September and celebrates its successful conclusion today with a scientific symposium at Forschungszentrum Jülich (FZJ). The HBP was one of the first flagship projects and, with 155 cooperating institutions from 19 countries and a total budget of 607 million euros, one of the largest research projects in Europe. Forschungszentrum Jülich, with its world-leading brain research institute and the Jülich Supercomputing Centre, played an important role in the ten-year project….
Researchers at Washington University in St. Louis have developed a new computational approach to removing movement in images of expanding and contracting heart cells and tissues. By computationally removing movement, the algorithm mimics a drug’s action in stopping the heart, without compromising cellular structure or tissue contractility. Results of the research, led by Nathaniel Huebsch, an assistant professor of biomedical engineering, and Guy Genin, the Harold and Kathleen Faught Professor of Mechanical Engineering, both at the McKelvey School of Engineering, are published…
… detects early signs of rejection. Wireless technology senses warning signs three weeks earlier than current methods. A body can reject a transplanted organ at any time — even decades later Signs of rejection must be caught early to intervene, preserve the organ Current monitoring methods are intermittent, imperfect and sometimes invasive New implant offers continuous monitoring by tracking the organ’s temperature When temperatures change, an alert is sent to a smartphone or tablet in real time Northwestern University researchers…
Opportunities for cancer treatment and wound healing. Cells are stimulated by robots measuring just 30 micrometers (µm) Technological platform developed to produce microrobots Ion channel mechanisms can be influenced A group of researchers at the Technical University of Munich (TUM) has developed the world’s first microrobot (“microbot”) capable of navigating within groups of cells and stimulating individual cells. Berna Özkale Edelmann, a professor of Nano- and Microrobotics, sees potential for new treatments of human diseases. A group of researchers at…
In living organisms, cells have a very high capacity to process and communicate information by moving molecules or ions through tiny channels that span the cell membrane. UC Santa Cruz Professor of Electrical and Computer Engineering Marco Rolandi’s lab and collaborators at MIT have created a device that mimics this biological concept in order to detect disease. Using their bioprotonic system, a device that integrates electronic components with biological components and uses electrical currents of protons, the researchers can detect…
Scientists investigate the unique absorption spectra of myelinated nerves as a way to visualize and differentiate them from their surroundings. Invasive medical procedures, such as surgery requiring local anesthesia, often involve the risk of nerve injury. During operation, surgeons may accidentally cut, stretch, or compress nerves, especially when mistaking them for some other tissue. This can lead to long-lasting symptoms in the patient, including sensory and motor problems. Similarly, patients receiving nerve blockades or other types of anesthesia can suffer…
Using a standardized assessment, researchers in the UK compared the performance of a commercially available artificial intelligence (AI) algorithm with human readers of screening mammograms. Results of their findings were published in Radiology, a journal of the Radiological Society of North America (RSNA). Mammographic screening does not detect every breast cancer. False-positive interpretations can result in women without cancer undergoing unnecessary imaging and biopsy. To improve the sensitivity and specificity of screening mammography, one solution is to have two readers…
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