International research team clarifies mode of action of cannabinoids in inflammation. While the German government is planning to relax legislation on the use of cannabis, researchers from the Friedrich Schiller University Jena, together with colleagues from Italy, Austria and the USA, have identified the mode of action underlying anti-inflammatory effects demonstrated by cannabinoids. A few days ago, the federal government took the controversial decision to make the acquisition and possession of small amounts of cannabis exempt from punishment. Provided the…
Working together with Chinese researchers, Münster physicists and chemists have, for the first time, produced long-chain mobile polymers on metallic surfaces, doing so by means of ballbot-type molecules which glide over the surface. Details of the work have been published in the journal “Nature Chemistry”. N-heterocyclic carbenes (NHCs) are small, reactive ring molecules which bond well with metallic surfaces and which, over the past few years, have attracted a great deal of interest in the field of the stable chemical…
Ants that leave the nest to forage are more likely to be infected by parasites than their nestmates who take care of the brood. In a new study in Nature Communications, an international research team including scientists at the Max Planck Institute for Chemical Ecology reports that, given the same genetic makeup, individual behavior alone determines whether or not an individual in a social group will contract a disease. Clonal raider ants of the species Ooceraea biroi that forage outside…
The computational design of new proteins for biomedical or other applications involves long computing times on powerful servers. A joint team of researchers from the Max Planck Institute for Biology Tübingen and the University Hospital Tübingen has now developed and tested a new computational method to greatly speed up the necessary energy calculations. Their framework, now published in the journal Cell Reports Methods, allows for a precise and efficient design of functional proteins. Evidencing the usefulness of their findings, the…
Though drug developers have achieved some progress in treating Alzheimer’s disease with medicines that reduce amyloid-beta protein, other problems of the disease including inflammation, continue unchecked. In a new study, scientists at The Picower Institute for Learning and Memory at MIT describe a candidate drug that in human cell cultures and Alzheimer’s mouse models reduced inflammation and improved memory. The target of the new “A11” molecule is a genetic transcription factor called PU.1. Prior research has shown that amid Alzheimer’s…
“Every successful medicine has its origin story. And research like this is the soil from which new drugs are born,” says Cold Spring Harbor Laboratory Professor Christopher Vakoc. For six years, Vakoc’s lab has been on a mission to transform sarcoma cells into regularly functioning tissue cells. Sarcomas are cancers that form in connective tissues like muscle. Treatment often involves chemotherapy, surgery, and radiation—procedures that are especially tough on kids. If doctors could transform cancer cells into healthy cells, it would…
Research team including Göttingen University describes seven new species of walking leaves. An international research team including the University of Göttingen has described seven previously unknown species of leaf insects, also known as walking leaves. The insects belong to the stick and leaf insect order, which are known for their unusual appearance: they look confusingly similar to parts of plants such as twigs, bark or – in the case of leaf insects – leaves. This sophisticated camouflage provides excellent protection…
Community circulation of ciprofloxacin-resistant E. coli paradoxically increased after six-year reduction in antibiotic prescriptions. After a nearly threefold drop in prescriptions for the antibiotic ciprofloxacin between 2015 and 2021, the rates of ciprofloxacin-resistant E. coli bacteria circulating in the community did not decline. In fact, a study of Seattle-area women over age 50 who had not taken any antibiotics for at least a year discovered that the incidence of gut-colonizing ciprofloxacin-resistant E. coli actually increased. About 1 in 5 women in the study were affected. Scientists…
The NSL complex is a key player in controlling intraciliary transport genes. Cilia are thin, eyelash-like extensions on the surface of cells. They perform a wide variety of functions, acting as mechanosensors or chemosensors, and play a crucial role in many signaling pathways. In the last few decades, the organelle has undergone a remarkable, but at the same time sinister, career transformation. It evolved from an organelle whose relevance was unclear to becoming a central player in the pathogenesis of…
…that could be used to quickly detect pathogens. The findings point to faster way to detect bacteria in food, water, and clinical samples. Getting results from a blood test can take anywhere from one day to a week, depending on what a test is targeting. The same goes for tests of water pollution and food contamination. And in most cases, the wait time has to do with time-consuming steps in sample processing and analysis. Now, MIT engineers have identified a…
A new study, led by Hirofumi Nakagami at the Max Planck Institute for Plant Breeding Research in Cologne, Germany, demonstrates that one of the two branches of plant immunity was likely to have evolved early during the establishment of plants on dry land. This insight into prehistoric plant immunity may have implications for breeding more resistant plant species. During plant terrestrialization, plants evolved from being aquatic organisms to those that live on land, a crucial shift in shaping the planet’s…
A team of chemists from the University of Münster developed a novel concept in which a mixture of molecules that behave like mirror images is converted to a single form. To this end, they use light as external energy source. The conversion is relevant e.g. for the preparation of drugs. The study is now published in the journal “Nature”. Just like our hands, certain organic molecules relate to each other like an image and its reflection – a phenomenon that…
When Dr. Bodo Beck first saw the three children of a family who had fled Syria sitting in his consultation room at University Hospital Cologne, the human geneticist was surprised. His genetic analysis diagnosed Bartter syndrome type 3, but never before had he seen such severe joint changes in patients with this rare disease. The kidney disease is hereditary – affected individuals lack the CLCNKB gene, which is responsible for a specific chloride channel. The electrolyte balance becomes disrupted because…
A tool for understanding the molecular mechanism of autism and the mind. Autism is difficult to study and more difficult to treat because it is an individual condition lacking precise quantification. The development of mouse models of human mental disorders has proven a tractable approach to studying the molecular mechanisms, a new review argues and highlights the current state of the art in autism research. Whether or not the autism spectrum is a disorder to be treated or a disability…
… unlocking the secrets to brain diseases. Nanoscale view of proteins opens window to treat neurodegenerative illness. Many diseases affecting the brain and nervous system are linked to the formation of protein aggregates, or solid condensates, in cells from their liquid form condensate, but little is known about this process. This liquid-to-solid transition can trigger the formation of what are called amyloid fibrils. These can further form plaques in neurons causing neurodegenerative diseases such as Alzheimer’s. Biomedical engineers at the…
Highly challenging to sequence and long overlooked, the human Y chromosome’s contributions to health and disease remain largely unknown. A new paper that presents, for the first time, the complete sequences of multiple human Y chromosomes from lineages from around the globe provides an essential step forward in understanding the roles of the Y chromosome in human evolution and biology. Even as the field of human genomics forged ahead at an astonishing pace, the Y chromosome— one of the sex…
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