Researchers from Osaka University have identified a protein called HKDC1 that’s crucial to maintaining two subcellular structures, mitochondria and lysosomes, thereby preventing cellular senescence. Just as healthy organs are vital to our well-being, healthy organelles are vital to the proper functioning of the cell. These subcellular structures carry out specific jobs within the cell, for example, mitochondria power the cell and lysosomes keep the cell tidy. Although damage to these two organelles has been linked to aging, cellular senescence, and…
For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat surfaces or require specificity for particular protein homologs. Typically, larger biologics that can target these proteins demand injection, limiting patient convenience and accessibility. In a new study published in Nature Chemical Biology, scientists from the laboratory of Professor Christian Heinis at EPFL have achieved a significant milestone in drug development….
A research team, led by Professor Yongwon Seo in the Graduate School of Carbon Neutrality at UNIST has unveiled a highly efficient method for desalinating seawater using hydrate-based desalination (HBD) technology. The breakthrough is expected to have far-reaching implications for the application of hydrate-based desalination techniques, with the ability to calculate optimal temperatures for enhanced efficiency. Hydrate desalination technology, known for its eco-friendly freshwater production capabilities, offers a low-energy solution that can be effectively used in treating high concentrations of brine or…
More sustainable and economical. This new method is based on the exsolution process activated by microwave radiation. Exsolution is a method of generating metallic nanoparticles on the surface of ceramic materials. “At elevated temperatures and in a reducing atmosphere (usually hydrogen), metal atoms migrate from the structure of the material to its surface, forming metal nanoparticles anchored to the surface. This anchoring significantly increases the strength and stability of these nanoparticles, which positively impacts the efficiency of these catalysts,” explains…
A drug screening system that models cancers using lab-grown tissues called organoids has helped uncover a promising target for future pancreatic cancer treatments, according to a new study from researchers at Weill Cornell Medicine. In the study, published Dec. 26 in Cell Stem Cell, the scientists tested more than 6,000 compounds on their pancreatic tumor organoids, which contain a common pancreatic cancer-driving mutation. They identified one compound—an existing heart drug called perhexiline maleate—that powerfully suppresses the organoids’ growth. The researchers…
At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days — but how? Regenerating functional tissue across species, including salamanders and insects, relies on the ability to form a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage. Jellyfish, along with other cnidarians such as corals and sea anemones, exhibit high regeneration abilities, but how they form the critical blastema has…
One of the major challenges facing cell research is how to target substances to combat diseases. A team from Constructor University, in cooperation with scientists from the University of Vienna, discovered a new, promising method using spherical metal oxide molecules known as polyoxometalates. They report on the results of their research in the journal “Advanced Materials”, one of the most important publication media in chemistry and materials science. The metal oxide molecules are already known as antitumor, antibacterial, antiviral and…
Light in the evening is thought to be bad for sleep. However, does the color of the light play a role? Researchers from the University of Basel and the Technical University of Munich (TUM) compared the influence of different light colors on the human body. The researchers’ findings contradict the results of a previous study in mice. Vision is a complex process. The visual perception of the environment is created by a combination of different wavelengths of light, which are…
Research at Göttingen and Warwick Universities reveals how filament interactions affect cellular networks. Tiny things matter – for instance, one amino acid can completely alter the architecture of the cell. Researchers at the Universities of Göttingen and Warwick investigated the structure and mechanics of the main component of the cytoskeleton of the cell: a protein known as actin. Actin is found in all living cells where it has a range of important functions – from muscle contraction to cell signalling…
Research groups around the world are developing technologies to convert carbon dioxide (CO2) into raw materials for industrial applications. Most experiments under industrially relevant conditions have been carried out with heterogeneous electrocatalysts, i.e. catalysts that are in a different chemical phase to the reacting substances. However, homogeneous catalysts, which are in the same phase as the reactants, are generally considered to be more efficient and selective. To date, there haven’t been any set-ups where homogeneous catalysts could be tested under…
Nanoscale patterns revealed within model research organism. Advanced instrument provides new 3D views of worm’s exoskeleton and clues about how skin layers are bound together. Species throughout the animal kingdom feature vital interfaces between the outermost layers of their bodies and the environment. Intricate microscopic structures—featured on the outer skin layers of humans, as one example—are known to assemble in matrix patterns. But how these complex structures, known as apical extracellular matrices (aECMs) are assembled into elaborately woven architectures has…
Research reveals molecular origins of function for a key drug target. Through an international collaboration, scientists at St. Jude Children’s Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand. They discovered precisely which amino acids control the key pharmacological properties of the ligand. The adrenaline receptor studied is a member of the G…
The Dynamic Journey of DNA Replication Timing and Its Impact on Cellular Plasticity . The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time. Scientists around Prof. Maria-Elena Torres-Padilla from Helmholtz Munich have recently…
New approach to vaccine development. Bioinformatics: Publication in Cell Systems Vaccine development aims at protecting as many people as possible from infections. Short protein fragments of pathogens, so-called epitopes, are seen as a promising new approach for vaccine development. In the scientific journal Cell Systems, bioinformaticians from Heinrich Heine University Düsseldorf (HHU) now present a method for identifying those epitopes that promise safe immunisation across the broadest possible population group. They have also computed vaccine candidates against the coronavirus SARS-CoV-2…
These tiny frogs lay their eggs on leaves, and the males guard them. In general, frogs’ teeth aren’t anything to write home about—they look like pointy little pinpricks lining the upper jaw. But one group of stream-dwelling frogs in Southeast Asia has a strange adaptation: two bony “fangs” jutting out of their lower jawbone. They use these fangs to battle with each other over territory and mates, and sometimes even to hunt tough-shelled prey like giant centipedes and crabs. In…
UW–Madison scientists engineer bacteria to make two valuable products from plant fiber. UW researchers have engineered bacteria that can produce two chemical products at the same time from underutilized plant fiber; The discovery could help make biofuels more sustainable and commercially viable. We often look to the smallest lifeforms for help solving the biggest problems: Microbes help make foods and beverages, cure diseases, treat waste and even clean up pollution. Yeast and bacteria can also convert plant sugars into biofuels…
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