– receptor clusters can direct cell movement Whether we smell, taste or see, or when adrenaline rushes through our veins, all of these signals are received by our cells via a specific group of receptor proteins called G protein-coupled receptors, which transmit signals to the inside of the cell. Biochemists at Goethe University Frankfurt and the University of Leipzig have now discovered that such receptors can also produce signals even in the absence of an external stimulus: It is apparently…
Koalas are facing multiple environmental and health issues which threaten their survival. Along with habitat loss – accelerated by last year’s devastating bush fires – domestic dog attacks and road accidents, they suffer from deadly chlamydial infections and extremely high frequency of cancer. An international team of scientists led by the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW) now demonstrate that a retrovirus invading the koala germline explains the high frequency of koala cancer. The results are reported in…
An undesirable effect can occur in super-resolution fluorescence microscopy: photoblueing. A new publication in „Nature Methods“ shows how it can be prevented or made useful for research. The latest developments in fluorescence microscopy make it possible to image individual molecules in cells or molecular complexes with a spatial resolution of up to 20 nanometres. However, under certain circumstances, an effect occurs that falsifies the results: the laser light used can cause very reactive oxygen molecules to form in the sample….
New flexible X-ray sensor suitable for next-generation medical and industrial applications. X-ray imaging is widely used in areas such as healthcare and forensic science, but existing X-ray machines are unable to capture curved three-dimensional (3D) objects at high resolution, and they are also relatively expensive. Now, an international team of researchers led by chemists from the National University of Singapore (NUS) has demonstrated a potential solution to overcome these limitations by using nanocrystals that can trap X-rays. The research, which…
In order to infect cells, SARS-CoV-2, the virus that causes COVID-19, needs to insert itself into the membrane of human cells; new molecular models show what parts of SARS-CoV-2 are critical for that interaction, revealing new potential drug targets. If the coronavirus were a cargo ship, it would need to deliver its contents to a dock in order to infect the host island. The first step of infection would be anchoring by the dock, and step two would be tethering…
Innovative method provides new insight into molecular processes involving RNA. Ribonucleic acid (RNA) is key to various fundamental biological processes. It transfers genetic information, translates it into proteins or supports gene regulation. To achieve a more detailed understanding of the precise functions it performs, researchers based at Heidelberg University and at the Karlsruhe Institute of Technology (KIT) have devised a new fluorescence imaging method which enables live-cell RNA imaging with unprecedented resolution. The method is based on a novel molecular…
How a single cell slime mold makes smart decisions without a central nervous system. Having a memory of past events enables us to take smarter decisions about the future. Researchers at the Max-Planck Institute for Dynamics and Self-Organization (MPI-DS) and the Technical University of Munich (TUM) have now identified how the slime mold Physarum polycephalum saves memories – although it has no nervous system. The ability to store and recover information gives an organism a clear advantage when searching for…
A simple but powerful idea is to improve the health of corals using cocktails of beneficial bacteria. The strategy is being explored as part of global scientific efforts to help corals become stronger, more stress resistant and more likely to survive bleaching events associated with climate change. Corals rely on bacterial and algal symbionts to provide nutrients, energy (through photosynthesis), toxin regulation and protection against pathogenic attacks. This complex and finely balanced relationship underpins the health of the holobiont and…
An international collaboration among researchers from Finland, Sweden, UK and the USA has captured ribosomes translating messenger RNA expressed from the maternally inherited mitochondrial genome. Utilising the latest advances in cryo-electron microscopy, the group discovered a novel mechanism that mitochondrial ribosomes use for the synthesis and delivery of newly made proteins to prevent premature misfolding. Disruptions to protein folding can lead to devastating human diseases. There is a familiar saying, “It’s all in the genes”. As modern archaeology reveals, the…
Like its chemical relative carbon dioxide (CO2), nitrous oxide (N2O) is an important greenhouse gas and the dominant ozone-depleting substance emitted in the 21st Century. Consequently, strategies for limiting its emissions and its catalytic decomposition with metals are being developed. A recent study indicates that nitrous oxide can bind to metals similarly to carbon dioxide, which helps to design new complexes with even stronger bonding. This could allow the use of nitrous oxide in synthetic chemistry or help to degrade…
The ability to turn a gene off only in a specific cell type is essential to modern life science. Thanks to the Cre-Controlled CRISPR it has just became simpler. The new method developed by researchers from the Center for Regenerative Therapies Dresden (CRTD) at TU Dresden with support from the DRESDEN-concept Genome Center (DCGC) offers a fast and easy approach for conditional gene inactivation. The findings were published in the journal “Nature Communications.” To discover the function of a gene…
Home gardens are by far the biggest source of food for pollinating insects, including bees and wasps, in cities and towns, according to new research. The study, led by the University of Bristol and published today in the Journal of Ecology, measured for the first time how much nectar is produced in urban areas and discovered residential gardens accounted for the vast majority – some 85 per cent on average. Results showed three gardens generated daily on average around a…
Capability could accelerate the development of new treatments for diseases. Northwestern University synthetic biologist Joshua Leonard used to build devices when he was a child using electronic kits. Now he and his team have developed a design-driven process that uses parts from a very different kind of toolkit to build complex genetic circuits for cellular engineering. One of the most exciting frontiers in medicine is the use of living cells as therapies. Using this approach to treat cancer, for example,…
Deep learning algorithms reveal rules of gene regulation With the help of artificial intelligence (AI) a German-American team of scientists deciphered some of the more elusive instructions encoded in DNA. Their neural network trained on high-resolution maps of protein-DNA interactions uncovers subtle DNA sequence patterns throughout the genome, thus providing a deeper understanding of how these sequences are organized to regulate genes. Artificial intelligence algorithms are extremely powerful at fitting massive and complex datasets. But their interpretation, rationalizing how the…
Magnetic nanoparticles biosynthesized by bacteria might soon play an important role in biomedicine and biotechnology. Researchers of the University of Bayreuth have now developed and optimised a process for the isolation and purification of these particles from bacterial cells. In initial tests, magnetosomes showed good biocompatibility when incubated with human cell lines. The results presented in the journal “Acta Biomaterialia” are therefore a promising step towards the biomedical use of magnetosomes in diagnostic imaging techniques or as carrier in magnetic…
During development, cells must specialize their function in a well defined timeline: formation of different tissues must be coordinated from a pile of cells. The research group led by Aneta Koseska (former Max Planck Institute of Molecular Physiology (MPI), CAESAR Bonn) has now developed a new theoretical concept that shows how cells specialize in right proportions in a coordinated manner through their communication with each other, and thus how new structures are formed and maintained. Stem cells are the all-rounders…
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