Lung cancer is the leading cause of cancer mortality worldwide and lung adenocarcinoma is the most common type. Many cases of lung adenocarcinoma are attributed to a mutation in a gene for the epidermal growth factor receptor (EGFR). Lung cancer with changes in EGFR is initially treatable with a family of chemotherapeutic agents called tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib. However, patients often develop resistance to these drugs through the acquisition of additional changes or secondary mutations…
When cells experience DNA damage, they'll try to repair it. But if that fails, the damaged cells are supposed to self-destruct, a process called apoptosis. A…
In the study, Graham George and colleagues note that mercury-based fillings, also called amalgams, have been used by dentists to repair teeth for well-over a…
Cells are not static. They can transform themselves over time — but change can have dangerous implications. Benign cells, for example, can suddenly change into…
A team of scientists from The University of Alabama used worms to reel in information that they hope will lead to a greater understanding of cellular…
The structure of the frosty flakes also fascinate ice chemists like Purdue University's Travis Knepp, a doctoral candidate in analytical chemistry who studies…
Spread by infected mosquitoes, West Nile virus was first detected in the United States in 1999. Since then, approximately 25,000 human cases have been…
“The real costs involved in any biofuel production are harvesting the goodies and turning them into fuel,” said Roy Curtiss, director of the Biodesign…
Researchers from the UCLA AIDS Institute and colleagues have for the first time demonstrated that human blood stem cells can be engineered into cells that can…
In an article published in the December 8 issue of Public Library of Science Biology, the authors described their experiments on the sex lives of fruit flies.”Can females be too good looking?” asks William Rice, biology professor at UCSB. “Can there be disadvantages to being attractive? The answer is yes: If you are too attractive, you get too much male attention, and that interferes with your ability to function biologically.”…
Transplanting human stem cells from umbilical cords onto the abnormally thin, cloudy corneas of laboratory mice significantly improved corneal transparency and…
The spread, or metastasis, of individual breast cancer cells from the main tumor into the blood circulation to the lungs and other body tissues and organs is…
These results, potentially relevant to research efforts to improve the treatment of patients with traumatic nerve damage or neurodegenerative disease, were…
Have you ever found yourself struggling to get your order taken at a crowded bar or lunch counter, only to walk away in disgust as more aggressive customers…
Researchers in Marburg, Germany find that exposure to environmental bacteria triggers a mild inflammatory response in pregnant mice that renders their…
The research will be published online in this week's Proceedings of the National Academy of Sciences. “This inverse relationship has been previously reported…
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