Toxicology experts have long known that individuals can exhibit a wide range of physiological responses when exposed to identical doses of opiate- or morphine-based drugs. This drug class includes illicit drugs such as heroin, as well as regulated drugs like methadone and oxycontin, which have legitimate uses in addiction treatment and pain management. Unfortunately, an individual’s response to these drugs can be gauged only after the drug has been administered, leaving care givers to make an educate
The culprit in bacterial streptococcus pharyngitis, or strep throat, can be vicious. Ask a parent who suspects their child has caught the virus, or the family of 29 Texans, including nine children, who died in 1997 after the bacteria manifested itself into a flesh eating disease. This virulent disorder used to cause physicians to order patients to immediately start taking antibiotics – even when a bacterial origin had not been established.
But taking antibiotics when not needed reduces the
Prescribed graded aerobic exercise is a simple, cheap, and effective treatment for people with fibromyalgia (medically unexplained chronic muscular pain and joint tenderness), finds a study in this week’s BMJ. Researchers identified 132 patients with fibromyalgia who were attending a hospital rheumatology clinic between January 1997 and June 1998. Patients were then randomly assigned to either aerobic exercise classes or relaxation classes, twice weekly for 12 weeks. The classes were carried out by p
Smoke-free workplaces not only protect non-smokers from the dangers of passive smoking, they also encourage smokers to quit or to reduce consumption, concludes a study in this week’s BMJ. Researchers in California reviewed 26 studies on the effects of smoke-free workplaces. Totally smoke-free workplaces were associated with reductions in prevalence of smoking of nearly 4%. The combined effects of people stopping smoking and reducing consumption reduces total cigarette consumption by 2
A synthetic antioxidant developed by researchers at National Jewish Medical and Research Center improves the survival of islet cells used in transplants for diabetes. The findings, reported in the August issue of the journal Diabetes by researchers at the University of Pittsburgh, could help overcome a significant drawback of the “Edmonton Protocol,” a promising treatment for diabetes. “The antioxidant neutralizes the harmful free radicals generated when islet cells are isolated from the pan
Many health advantages have been attributed to soy isoflavones, which are components of soy-protein foods, yet it is still unclear to what extent the isoflavones themselves are responsible for these benefits. In a new study published in the American Journal of Clinical Nutrition, Jenkins et al. compared the effects of a low-saturated fat control diet, and soy-protein diets with either a high or low isoflavone content in the context of their effects on risk for coronary artery disease. Compared with t
People who consume alcohol in moderation are healthier, yet the relationship between alcoholic beverage preference and health benefit or risk has not been extensively investigated. In a new study published in the American Journal of Clinical Nutrition, Barefoot et. al. surveyed alcoholic beverage preference in a large and homogeneous group of highly educated upper-income Americans and found that beverage choice has implications beyond the relative physiological benefits of alcohol. Wine drinking has
Researchers at Case Western Reserve University have discovered kinks in aggrecan, a widely studied protein at the submolecular root of arthritis, a finding that brings scientists closer toward new drugs and other interventions to prevent or alleviate the disease. “Aggrecan acts to organize and densely pack sugar molecules that give cartilage its resilience,” said Steven Eppell, an assistant professor of biomedical engineering and director of the Nanoscale Orthopedic Biomaterials Labo
The only known adults in the world who possess a rare genetic mutation that prevents their bodies from producing leptin may open the door to a new way of fighting fat. After injections with leptin — a human hormone linked to appetite control — the adults’ dramatic weight loss suggests that leptin offers significant promise for treating obesity. Dr. Julio Licinio, professor of medicine at the David Geffen School of Medicine at UCLA, flew three cousins — two women and one man — from a
University of Minnesota Cancer Center researchers have found that morphine, which is routinely given to cancer patients to manage severe pain, actually stimulates signals in endothelial cells that in turn prompt tumors to grow in mice. The study will be published in the Aug. 1 issue of Cancer Research. Kalpna Gupta, Ph.D., assistant professor in the hematology, oncology and transplantation division of the university’s department of medicine and lead author of the study, found that doses of morp
Scallops, oysters and mussels – the best of fare Scotland`s kitchens have resulted in a top Parisian award for a researcher from the University of Dundee. Matthew Gubbins is not a chef but a scientific expert on toxicity in shellfish. Matthew (26) has scooped the Daniel Jouvance award for his work on how shellfish become toxic and then lose their toxicity again in the sea. Identifying these processes will allow the industry to monitor more closely when shellfish are non-toxic , ready for harvest a
New study looks at link between ADHD symptoms and smoking in a community sample of high school students Adolescents with symptoms of attention-deficit/hyperactivity disorder (ADHD) are more likely to experiment with smoking and become regular tobacco users, a study by researchers from the University of Pennsylvania School of Medicine and Georgetown University indicates. This study appears in the July issue of the Journal of the American Academy of Child and Adolescent Psychiatry. ADHD i
Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening? BMJ Volume 325, pp 157-60 Recent evidence suggests that women with a history of complications in pregnancy may be at increased risk of diabetes and heart disease in later life. Researchers in this week’s BMJ suggest that these women should be screened and given relevant health education. Women who develop diabetes during pregnancy (a condition known as gestational diabetes) are
When a man is first diagnosed with prostate cancer, the initial visit to the doctor becomes a blur. Complex decisions about treatment now face the patient, yet formulating adequate questions is often difficult. Further clouding the picture is the tendancy of some physicians to only recommend treatment options in which they specialize. To empower patients facing these difficult and complex decisions, Temple University’s College of Engineering and the Fox Chase Cancer Center (FCCC), armed
In a groundbreaking telemedicine development, doctors in Massachusetts earlier this month helped a physician at Amundsen-Scott South Pole Station to surgically repair the damaged knee of a meteorologist spending the winter in Antarctica. Using a “telemedicine” connection operated by Raytheon Polar Services Co. (RPSC) of Centennial, Colo., orthopedic surgeon Bertram Zarins and anesthesiologist Vicki Modest, both of Massachusetts General Hospital in Boston, helped South Pole physician Dr. Timothy Polla
As Congress considers legislative proposals aimed at saving Medicare+Choice, a new study published today on the Health Affairs Web site shows that under the best-case scenario, enrollment in the troubled managed care program would stabilize at about 5 million beneficiaries. Under the worst case of the four policy proposals to boost sluggish M+C reimbursement, enrollment would shrink to just 3.3 million by 2005, according to the article by health care scholars Kenneth E. Thorpe and Adam Ather
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