To identify the best treatment for recurrent ovarian cancer, researchers at Yale School of Medicine are studying a technology called the Yale apoptosis assay in combination with another technology called the ChemoFX assay, which could double the response rate to existing drugs.
In patients with recurrent ovarian cancer, it is often difficult to select an effective treatment because the tumor develops resistance to many drugs. Currently, physicians select a drug and must wait abo
Even before making the connection between drugs such as Vioxx and heart attacks, many doctors were becoming concerned that the heavily advertised drugs known as COX-2 inhibitors were being over-used, often by patients unlikely to benefit from this costly but innovative pharmaceutical class.
In the January 25, 2005, issue of the Archives of Internal Medicine, researchers from the University of Chicago and Stanford University School of Medicine use data from the National Center
Older women who drink a moderate amount of alcohol each day may be helping to keep their minds sharp, according to researchers at Wake Forest University Baptist Medical Center and colleagues.
“In our study, older women who drank moderate amounts of alcohol tended to perform better on tests for cognitive function and dementia,” said Mark Espeland, Ph.D., lead researcher. “Most of these women drank one or two drinks per day.”
The researchers used data from the Women’s
As the death toll from the Dec. 26 earthquake and tsunami climbed above 200,000, a University of Washington psychologist who just returned from Indonesia warned of a new danger among the survivors – a mental health crisis.
“We are seeing children petrified by seeing water in a tub or cowering when large airplanes are flying overhead because they sound like rushing water,” said Randall Kyes, a research associate professor of psychology and head of the division of international
Results from a Mayo Clinic laboratory study in animals suggest that using distraction osteogenesis, a procedure that uses the mechanical force of an appliance to lengthen soft tissue and bone, may be a feasible and effective method to repair cleft palate in the future. Cleft palate is a common birth defect in which a child is born with a gap in the roof of the mouth. This condition occurs in one out of 700 to 1,000 births in the United States.
“Right now, nobody tries to close
A review of recent studies concludes that surgeons should perform vaginal rather than abdominal hysterectomies whenever possible in order to cut down on complications and the length of hospital stays.1
According to the systematic evidence review by Dr. Neil Johnson of the University of Auckland in New Zealand and colleagues, women who had vaginal hysterectomies had fewer infections and high temperatures after surgery compared to those who had abdominal hysterectomies. Women
The common use of anti-inflammatory steroids for traumatic head injuries like those from car crashes may actually increase the risk of death, according to a new review of studies about the treatment.1
A previous review found there was not enough evidence to recommend that routine use of steroids be stopped. This newer analysis published by the British-based Cochrane Library draws heavily from a recent study of corticosteroid treatment for brain injury, including coma and conc
A molecule specially modified by researchers at Baylor College of Medicine can reset the biological clock for cancer vaccines, potentially making them more potent.
In a report that appears online today in Nature Medicine, Dr. David Spencer and colleagues describe their method of delaying the time at which crucial dendritic cells are activated by the immune system. This prolongs the time during which the cancer vaccines can undertake their task, he said.
Dendritic cells a
Researchers say obesity is associated with lower prostate specific antigen (PSA) levels in men, making the screening test likely to produce unreliable results in this population. The full study is published in the March 1, 2005 issue of CANCER (http://www.interscience.wiley.com/cancer-newsroom), a peer-reviewed journal of the American Cancer Society.
Since the use of early detection tests for prostate cancer became relatively common (about 1990), the prostate cancer death rate h
The prevailing medical understanding of seizures in the weeks just after epilepsy surgery is that they are likely to be temporary, probably due to swelling or minor trauma suffered by the brain during the operation.
In fact, early seizures after the most common form of epilepsy surgery signal a greatly increased likelihood that the patient will continue to have seizures, according to a study published online January 24, 2005, in the Annals of Neurology (http://www.interscience
The Tekniker Foundation, together with the company EuroOrtodoncia S.L., is designing a new range of orthodontic brackets which have minimum visual or aesthetic impact and which are manufactured by means of microinjection techniques. Dental brackets are small items employed in orthodontics for the correct alignment of the teeth.
The dental bracket market is in full swing worldwide for a number of reasons. In western societies this growth is due to the fact that criteria over buc
Researchers from Washington University School of Medicine have shown that an antibody treatment administered to the brain surface in mice with Alzheimer disease is capable of rapidly reversing disease-related structural nerve damage. The study will appear online on January 20 in advance of print publication in the February 1 issue of the Journal of Clinical Investigation.
One of the many hallmarks of Alzheimer disease is the presence of deposits or “plaques” made up of amyloid-
University of Pittsburgh findings published in leading European journal
Reduced blood concentrations of a protein called adiponectin appear to indicate a significant risk of cardiovascular disease in one of the first studies to focus on risk of the disorder among patients with diabetes mellitus type 1, previously known as juvenile diabetes. Recent studies suggest that adiponectin, a protein specific to fat tissue, is involved in obesity, diabetes and heart disease. Results of the s
Supplement projects future possibilities and partnering with patients in providing care
A special supplement to the Society of Nuclear Medicine’s Journal of Nuclear Medicine examines current and future uses of radionuclide therapy and its importance in medical practice and patient management.
Supplement editors Steven M. Larson, M.D., and Eric P. Krenning, M.D., Ph.D., present a comprehensive overview intended to offer relevant advice to nuclear medicine practitioners
Researchers have discovered a link between the amount of blood flowing through the liver of the unborn baby in late pregnancy and the diet of expectant mums. In slim mothers and those who eat an unbalanced diet the amount of blood flowing to the liver is increased. While this ‘liver-sparing’ pattern of blood flow is thought to protect the foetus from a nutrient deficit, the researchers believe it may also affect liver function in later life, increasing the risk of adult heart disease and diabetes
Why is it that when you go on holiday some members of your family always seem to get bitten more than others? Researchers supported by the Biotechnology and Biological Sciences Research Council (BBSRC) think they may have found the answer and their work could lead to new types of insect repellent.
James Logan, a research student at the BBSRC-sponsored institute Rothamsted Research in Hertfordshire, has found that some people give off “masking” odours that prevent mosquitoes f
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