More than seven million people in Germany suffer from diabetes. Drug research is still difficult. Scientists led by Peter Loskill from the NMI and the University of Tübingen have developed a technique that significantly improves the view on the molecular and cell biological level in the pancreas. More than seven million people in Germany suffer from diabetes. At the same time, research into drugs to treat this widespread disease is still difficult. Scientists led by Prof. Dr. Peter Loskill from…
Applied during endoscopic procedures, GastroShield could help prevent complications such as bleeding and leakage from weakened gastrointestinal tissues. More than 20 million Americans undergo colonoscopy screenings every year, and in many of those cases, doctors end up removing polyps that are 2 cm or larger and require additional care. This procedure has greatly reduced the overall incidence of colon cancer, but not without complications, as patients may experience gastrointestinal bleeding both during and after the procedure. In hopes of preventing…
– and they are associated with an increased risk of cardiovascular diseases. Researchers at DZNE provide evidence that traces of the widely used PFAS chemicals in human blood are associated with unfavorable lipid profiles and thus with an increased risk of cardiovascular diseases. The findings are based on data from more than 2,500 adults from Bonn and the Dutch municipality of Leiderdorp. PFAS were detectable in the blood of nearly all study participants. The study results have been published in…
Zika virus vaccine emerges as an unlikely hero in battling brain cancer. The scientists discovered that Zika virus vaccine strains eradicate brain tumour cells while sparing healthy ones. Scientists from Duke-NUS Medical School (Duke-NUS) have developed a new approach using the Zika virus to destroy brain cancer cells and inhibit tumour growth, while sparing healthy cells. Using Zika virus vaccine candidates developed at Duke-NUS, the team discovered how these strains target rapidly proliferating cells over mature cells—making them an ideal…
MHH researchers place living human heart tissue in a nutrient solution and use it to test new drugs and innovative approaches to combat heart failure. MicroRNAs (miRNAs) are also involved in the development of diseases. These small RNA snippets belong to the so-called non-coding RNAs: although they do not contain any genetic information for the production of a protein, they fulfil an important task in the control of fundamental biological processes in our cells. They therefore offer a new starting…
NIH trial reveals need for more accurate screening in Black people and cisgender women. The elevated cardiovascular disease risk among people with HIV is even greater than predicted by a standard risk calculator in several groups, including Black people and cisgender women, according to analyses from a large international clinical trial primarily funded by the National institutes of Health and presented at the 2024 Conference on Retroviruses and Opportunistic Infections (CROI) in Denver. The risk of having a first major…
Underlying mechanism for the development of T follicular helper cells deciphered. T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer. Researchers from the University Hospital Bonn (UKB) and the Cluster of Excellence ImmunoSensation2 at the University of Bonn investigated the underlying mechanisms of Tfh cell development in a mouse model and thus decoded…
Study: Active ingredient evaluation for nerve regeneration. Injury- or disease-induced nerve damage often leads to permanent impairment in motor function, sensitivity, or chronic pain. For affected patients, this results in a significant loss of their quality of life. Nearly eight percent of Europeans older than 55 suffer from so-called peripheral neuropathies. A research team from the Center for Pharmacology in Cologne now presents a new study in which a promising compound for nerve regeneration was investigated. Longitudinal sections of damaged…
Bonn researchers find connection between autobiographical memory and aphantasia. When people lack visual imagination, this is known as aphantasia. Researchers from the University Hospital Bonn (UKB), the University of Bonn and the German Center for Neurodegenerative Diseases (DZNE) investigated how the lack of mental imagery affects long-term memory. They were able to show that changes in two important brain regions, the hippocampus and the occipital lobe, as well as their interaction, have an influence on the impaired recall of personal…
Researchers from Carnegie Mellon University, the University Hospital Bonn and the University of Bonn have created an open-source platform known as A-SOiD that can learn and predict user-defined behaviors, just from video. The results of the study have now been published in the journal “Nature Methods”. “This technique works great at learning classifications for a variety of animal and human behaviors,” said Eric Yttri, Eberly Family Associate Professor of Biological Sciences at Carnegie Mellon. “This would not only work on…
New findings on the link between myotonic dystrophy 2 and autoimmune diseases. Researchers at the University Hospitals of Dresden and Bonn of the DFG Transregio 237 and from the Cluster of Excellence ImmunoSensation2 at the University of Bonn have made progress clarifying why patients with myotonic dystrophy 2 have a higher tendency to develop autoimmune diseases. Their goal is to understand the development of the disease, and their research has provided new, potential therapeutic targets. The results of the study…
… is a big step forward. Lung cancer is one of the most common cancers and has one of the lowest survival rates in the world. Cytokines, which are small signaling proteins, such as interleukin-12 (IL-12), have demonstrated considerable potential as robust tumor suppressors. However, their applications are limited due to a multitude of severe side effects. In a paper published Jan. 11 by Nature Nanotechnology, Biomedical Engineering Professor Ke Cheng and his research group demonstrate that using nanobubbles, called exosomes, through an inhalation treatment method…
MHH junior researcher investigates the influence of the immune system on age-related disorders of sensory neurones. The peripheral nervous system includes sensory and motor nerve cells that run through our body in bundles like power cables. Motor nerve cells transmit instructions from the brain to the muscles. Sensory nerve cells inform us about our position in the environment and what is happening in our body. They transmit stimuli from the sensory organs to the brain – i.e. what we see,…
Neuroscientists from Bonn, New York, and Freiburg discover interactions between so-called “ripples” and nerve cells during human memory processes. Spatial navigation and spatial memory play a central role in our lives. Without these abilities, we would hardly be able to find our way around our surroundings and would find it difficult to remember past events. However, the neuronal basis of spatial memory is far from being fully understood. A research group led by Prof. Lukas Kunz, who has recently joined…
A new bonding method enabling instant and effective adhesion of hydrogels has potential to broadly advance new biomaterials solutions for multiple unmet clinical needs. Hydrogels are versatile biomaterials conquering an increasing number of biomedical areas. Consisting of water-swollen molecular networks that can be tailored to mimic the mechanical and chemical features of various organs and tissues, they can interface within the body and on its outer surfaces without causing any damage to even the most delicate parts of the human…
…sounds alarm regarding circulation of this virus in urban environments. The opossum was found dead in a park in the center of Campinas, a large city in São Paulo state (Brazil), with the same viral variant as fruit-eating bats. These mammals are regularly detected in cities, where they are often attacked by dogs. A female White-eared opossum (Didelphis albiventris) found dead in 2021 in Bosque dos Jequitibás Park in the center of Campinas, one of the largest cities in São…
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