The microbiota in the intestines fuels tumour growth

Prof. Dirk Haller discovered that it is not cell stress alone that leads to tumour growth, but the cooperation of stress and microbiota - here with Sandra Bierwirth (left) and Olivia Coleman. A. Heddergott/ TUM

“With our study we originally wanted to study the role of bacteria in the intestines in the development of intestinal inflammation,” explains Professor Dirk Haller from the Department of Nutrition and Immunology at the Weihenstephan Science Centre of the TUM.

“However, the surprising result for us was the discovery that bacteria together with stress in cells caused tumours (exclusively in the colon) and without the involvement of inflammation”.

The investigations were initially carried out using the mouse model. In germ-free (i.e. sterile) animals, in which the activated transcription factor ATF6 regulated stress in the intestinal mucosa (intestinal epithelium), no change could be observed.

But as soon as the microbiota, i.e. all the microorganisms in the intestine, were transplanted back into germ-free animals, tumours developed in the colon of the mice. Using Koch's postulates, Haller and his team were able to show that microorganisms are involved in the development of cancer in the colon.

The transcription factor ATF6 regulates stress in cells, and the intensity and duration of activation is increased with diseases. “However, it is not cell stress alone that leads to tumour growth, but the combination of stress and microbiota that favours cancer growth,” says Haller, head of ZIEL – the Institute for Food & Health at TUM.

ATF6 incidence found to be increased in colon cancer patients

Subsequently, in cooperation with the clinic on the right side of the Isar (Prof. Janssen), the data of 541 patients with colon cancer were examined. In those cases where the level of transcription factor ATF6, which triggers cell stress, was significantly increased, the recurrence rate after surgery increased: About ten percent of patients were at risk of getting colon cancer a second time.

“In certain patients, the protein ATF6 could serve as a diagnostic marker for an increased risk of colon cancer and could indicate the start of therapy at an early stage,” said Prof. Haller – “a microbial therapy is conceivable, when we know more about the composition of the bacterial flora. What now became clear, however: Chronic inflammation has no effect on cancer development in the colon.”

More Information:
This work was funded by the DFG Research Fellowship (RTG) 1482, the DFG Focus Program (SPP) 1656 and the DFG Special Research Program (SFB) 1335.

Prof. Dr. Dirk Haller
Technical University Munich
Chair of Nutrition and Immunology
ZIEL – Institute for Food & Health (Director)
Phone.: +49-(0)8161-712026
Mail: dirk.haller@tum.de

Olivia Coleman, Elena Lobner, Sandra Bierwirth, Adam Sorbie, Nadine Waldschmitt, Eva Rath, Emanuel Berger, Ilias Lagkouvardos, Thomas Clavel, Kathleen McCoy, Achim Weber, Mathias Heikenwälder, Klaus-Peter Janssen and Dirk Haller: Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis, Gastroenterology 9/2018.
DOI: 10.1053/j.gastro.2018.07.028

https://www.tum.de/nc/en/about-tum/news/press-releases/detail/article/34947/

Media Contact

Dr. Ulrich Marsch Technische Universität München

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

China claims new world record for strongest steady magnetic field

The hybrid magnet at the Steady High Magnetic Field Facility (SHMFF) in Hefei, China set a world record for the highest steady magnetic field by a working magnet when it…

Metaholographic platform that detects light exposure

During the COVID-19 pandemic last year, an incident occurred where vaccines exposed to room temperature had to be discarded. Biomedical substances, including vaccines, risk deterioration if not stored properly, so…

Similarity of hepatocytes from liver and from stem cells improved

Research with stem cells is becoming increasingly important, because stem cells can develop into any body cell – skin cells, nerve cells or organ cells such as liver cells, the…

Partners & Sponsors