Over the past few years, covalent modifications of histone tails have emerged as an important mechanism of gene regulation in eukaryotes. Now, scientists have identified a major euchromatic histone methyltransferase in mammalian cells that is crucial for normal embryonic development, and possibly the prevention of cancer. In a report published in Genes & Development, Dr. Yoichi Shinkai and colleagues have identified a protein called G9a as an enzyme that adds a methyl group to the lysine 9 amino acid
A team of Johns Hopkins researchers has identified and successfully tested in animals a potential new treatment for liver cancer, a disease for which there are few effective treatments. Writing in the July 15 issue of Cancer Research, the scientists report that only cancer cells were killed when the compound, 3-bromopyruvate, was given to rabbits with experimental liver tumors. “It’s very exciting because we expected the compound to be pretty toxic, but somehow normal c
One or two drinks a day can raise the risk of developing hypertension in some men, according to two Japanese studies. The studies, published in the July issue of Alcohol: Clinical Experience and Research, found that men who had as few as one or two glasses of alcohol on a regular basis had a much higher incidence of hypertension than those who did not drink at all. Several U.S. studies have found that moderate drinking habits can actually decrease the risk of heart disease. A
An enzyme whose activity is affected by alcohol may prove useful in identifying recent alcohol or marijuna use even though it does not seem to be a good marker for genetic predisposition to alcoholism, a new international study finds. The researchers also found that the activity level of the enzyme, adenylyl cyclase, steadily dropped in people who had abstained from drinking for days to weeks and was generally lower in people with a history of major depression, according to the study published in th
Popeye was right — eat your spinach. In fact, add some fresh-cut apples to that spinach salad.
Two new animal studies by researchers at the University of South Florida Center for Aging and Brain Repair and James A. Haley Veterans Hospital bolster a growing body of evidence that certain fruits and vegetables may protect the brain against the ravages of age. The complementary research papers appear in today’s issue of the Journal of Neuroscience.
“If these pre-clinical fin
A sensor aboard NASA’s Terra satellite is helping scientists map how much sunlight the Earth’s surface reflects back up into the atmosphere, and this new detailed information should help to greatly improve weather and forecast models. The Moderate Resolution Imaging Spectroradiometer (MODIS) now routinely provides daily global and local measurements of albedo, or the total amount of light reflected from Earth’s surface out to space. These precise data may allow scientists to better understand and pr
As part of the Earth System Science Pathfinder small-satellite program, NASA has selected a new space mission proposal led by NASA’s Goddard Space Flight Center in Greenbelt, Md., that will yield fresh insight into how oceans affect and respond to climate change — knowledge that will help better life here on Earth. The mission, named Aquarius, promises to explore the saltiness of the seas in order to understand how the massive natural exchanges of water between the ocean, atmosphere and sea ice
The U.S. Food and Drug Administration has asked for additional information, but no additional clinical trials, as it considers approval of FluMist, an influenza vaccine delivered as a nasal spray. FluMist was invented by Hunein “John” Maassab after more than four decades of research at the University of Michigan School of Public Health. Gaithersburg, Md.-based MedImmune has licensed the rights to FluMist from U-M, and has a marketing agreement with pharmaceutical giant Wyeth. “I am
Dr. Irv Binik investigates pain during intercourse For some women sex can be uncomfortable. For others it can be downright painful. Dr. Irv Binik, a Psychology professor at McGill and director of the Royal Victoria Sex and Couples Therapy Service is trying to ease the pain. He has been studying the problem of sex-associated pain in women, paying particular attention to two recurrent acute conditions, pain during or after intercourse (dyspareunia) and involuntary spasms of the vagina (v
An astrophysicist from Lawrence Livermore National Laboratory’s Institute for Geophysics and Planetary Physics has found that some nanodiamonds, the most famous and exotic form of stardust, may instead have formed within the inner solar system. The findings argue with the wide held belief that nanodiamonds recovered from meteorites from the asteroid belt have been the most abundant type of presolar stardust grain. IGPP Director John Bradley, in conjunction with scientists from the Georg
Children in America are less likely to die during infancy than they were in previous years, less likely to smoke in 8th or 10th grade, and less likely to give birth during adolescence, according to the 6th annual report, America’s Children: Key National Indicators of Well-Being, 2002. The report also noted improvements in some of the economic security indicators: children are more likely to have at least one working parent and to have health insurance. Moreover, children from ages 3 to 5 are mor
Ecological communities suffer dramatic changes when non-native species are introduced by humans. Such introductions have been documented in hundreds of locations and appear to be common in marine and island habitats. One of the best-studied cases of a species that suddenly appeared in the New England intertidal, and subsequently spread rapidly southward accompanied by significant changes in the intertidal community, is the “European periwinkle” Littorina littorea. In the July issue of Ecolog
French birds love the smell of perfumed nests. In an article published this month in Ecology Letters, scientists from the Centre National de Recherche Scientifique report that a small cavity-nesting bird on the island of Corsica, the blue tit, adorns its nests with fragments of strongly perfumed plants, including lavender and mint. The chemical compounds of these plants are economically important as they are used for aromatic house cleaners and herbal medicines. The researchers also discovered that t
Prey have evolved a suite of tricks to avoid falling victim to a predator. They may escape, hide, protect, become toxic/inedible or defend themselves. In principle, they could also scare the predator away, but this is risky when predators are big. Recent work led by a Dutch research team and published in the July issue of Ecology Letters revealed that a plant-feeding thrips insect overcomes this differential size problem by killing the eggs of its enemy, a plant-inhabiting predatory mite. Th
Disease-free survival from advanced prostate cancer could be almost doubled if hormone-suppression therapy is used during and after radiotherapy for a duration of 3 years, suggest authors of an international study in this week’s issue of THE LANCET.
Long-term survival after radiotherapy for people with advanced prostate cancer is poor. Michel Bolla from University Hospital, Grenoble, France, and colleagues investigated the added value of long-term male-hormone (androgen) suppression in locally ad
Interrupting anti-HIV treatment for an extended period and then re-initiating therapy might be safe in some patients, according to a study by Northwestern University infectious disease experts. Chad Achenbach, M.D., and co-investigators from The Feinberg School of Medicine presented data from their research today at the XIV International AIDS Conference. In an observational study, 25 HIV-infected patients with viral suppression for at least six months while receiving highly active a
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