Researchers from Finland have found that the cholesterol-lowering agent gemfibrozil (marketed as Lopid and generics) greatly increases the concentrations of cerivastatin (Lipobay or Baycol) in blood. This finding explains the observed muscle toxicity of the gemfibrozil-cerivastatin combination. This potentially fatal adverse effect of cerivastatin led to the withdrawal of Lipobay/Baycol from the market.
The concentrations of Lipobay were increased on average 5-6-fold by Lopid, in some indivi
Scientists at the University of Pennsylvania School of Veterinary Medicine have found a new wrinkle in the developmental biology dogma that cell differentiation occurs irreversibly as stem cells give rise to increasingly specialized types of offspring cells. The researchers have shown that certain mouse cells retain an ability to oscillate between very distinct blood cell types — B-cells and macrophages — long after what has been commonly regarded as the point of no return.
These latest fi
In the battle against cancer, Virginia Tech researchers have developed a potential warhead to better kill cancer cells, a new missile to deliver the warhead more efficiently to the diseased areas, and a new detonation device once the warhead is in place.
In a cross-disciplinary effort, the researchers, using photodynamic therapy (PDT), have obtained results in three different areas that, used together, have the possibility of providing more efficient, less invasive, and more specific treatm
High-power ultrasound, currently used for cell disruption, particle size reduction, welding and vaporization, has been shown to be 99.99 percent effective in killing bacterial spores after only 30 seconds of non contact exposure in experiments conducted by researchers at Penn State and Ultran Labs, Boalsburg, Pa.
In the experiments, bacterial spores contained in a paper envelope, were placed slightly (3mm) above the active area of a specially equipped source of inaudible, high frequency (70
Honeybees communicate by dancing. The dances tell worker bees where to find nectar. A UC Riverside study reports that under natural foraging conditions the communication of distance and direction in the dance language can increase the food collection of honeybee colonies. The study also confirms that bees use this directional information in locating the food sources advertised in the dance.
Based on work done in 2001 in the Agricultural Experiment Station at UC Riverside, P. Kirk Visscher,
A key role in synchronizing daily rhythms to the day/night cycle has been traced to a light-sensitive protein in the eye, by knocking out the gene that codes for it. Mice lacking a gene for the photopigment melanopsin show a dramatic deficiency in their ability to regulate their circadian rhythms by light. The discovery, by National Institute of Mental Health (NIMH) grantees, helps unravel the heretofore elusive mechanisms by which day/night cycles regulate such rhythms in mammals. NIMH grantees Igna
Dr. Mario Capecchi and colleagues at the University of Utah and the Department of Veterans Affairs Medical Center (Salt Lake City, UT) have discovered that a gene called xanthine oxidoreductase, or XOR for short, is required for lactation in female mice. This previously unidentified role for XOR in lactation reveals a possible genetic basis for the lactation difficulties experienced by nearly 5% of women.
XOR was originally identified as encoding an enzyme involved in purine catabolism (the
A collaboration of scientists from Harvard Medical School and Dartmouth Medical School has developed a new mouse model of lipoatrophic diabetes, and highlighted leptin therapy as a successful tool to combat this rare form of type II diabetes.
Lipoatrophic diabetes mellitus is characterized by a lack of subcutaneous fat (lipoatrophy), high blood sugar (hyperglycemia), and high blood insulin (hyperinsulinemia). Because patients with lipoatrophic diabetes are insulin-resistant, although high l
Researchers at Cedars-Sinai Medical Center’s Maxine Dunitz Neurosurgical Institute in Los Angeles have combined a special protein that targets cancer cells with neural stem cells (NSC) to track and attack malignant brain tumor cells. Results of their study appear in the Dec. 15 issue of Cancer Research.
Glioblastoma multiforme, or gliomas, are a particularly deadly type of brain tumor. They are highly invasive with poorly defined borders that intermingle with healthy brain tissue, maki
Scientists at the University of Virginia School of Medicine have discovered a new contributor to atherosclerosis, the most common form of hardening of the arteries. Marked by cholesterol-calcium-lipid deposits, atherosclerosis is the main cause of heart attacks, the number one killer in the U.S. Doctors at U.Va. say research on mice has determined for the first time that activated platelets circulating in the blood, long understood as markers for atherosclerosis, really serve as participants in the p
Vanderbilt University Medical Center investigators are reporting success with a novel gene therapy approach. Working with cells grown in the laboratory, the group is the first to repair a defective gene and demonstrate that the resulting protein product is functional, said Dr. Alfred L. George Jr., senior author of a study published Dec. 15 in the Journal of Clinical Investigation.
Although use of the approach in patients is still years in the future, the findings are an important step in sh
Forget the robot child in the movie “AI.” Vanderbilt researchers Nilanjan Sarkar and Craig Smith have a less romantic but more practical idea in mind.
“We are not trying to give a robot emotions. We are trying to make robots that are sensitive to our emotions,” says Smith, associate professor of psychology and human development.
Their vision, which is to create a kind of robot Friday, a personal assistant who can accurately sense the moods of its human bosses and respond appropriate
It is commonplace for patients with Acute Lung Injury (ALI) to be injected with a dye, known as contrast material, before undergoing a CT (computerized tomography) scan of their lungs. Contrast material helps enhance the image so that doctors can evaluate the state of a patient’s lungs. New research published in Critical Care shows that using contrast material could worsen the condition of patients suffering from ALI because it causes the lungs to fill up with fluid, making it more difficult for
Using a powerful new instrument at the South Pole, a team of cosmologists has produced the most detailed images of the early Universe ever recorded. The research team, which was funded by the National Science Foundation (NSF), has made public their measurements of subtle temperature differences in the Cosmic Microwave Background (CMB) radiation. The CMB is the remnant radiation that escaped from the rapidly cooling Universe about 400,000 years after the Big Bang. Images of the CMB provide researchers
Work has implications for repairing human heart muscle after heart attacks
Experiments on zebrafish provide important clues that could eventually lead to the ability to regenerate damaged human heart muscle, say researchers from the Howard Hughes Medical Institute at Children’s Hospital Boston. Reporting in the Dec. 13 issue of Science, a team led by HHMI investigator Mark T. Keating, MD, senior associate, department of Cardiology, showed for the first time that zebrafish can reg
Impacts on ecosystems are greater than previously anticipated
Projected increases in rainfall variability resulting from changes in global climate can rapidly reduce productivity and alter the composition of grassland plants, according to scientists funded by the National Science Foundation (NSF). Although the diversity of plant species is increased in this scenario, the most important or dominant grasses were more water-stressed and their growth was reduced. Carbon dioxide release by
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