Researchers have combined novel molecular targeting technologies to deliver gene-silencing therapy specifically to tumor cells shielded by a normally impermeable obstacle, the blood brain barrier.
In the June 1 issue of the journal Clinical Cancer Research, William Pardridge, M.D., UCLA, reported that a delivery packet equipped with two specific antibodies first recognizes the transferrin receptor, a key protein portal in the blood brain barrier, and then gains entry into brain cancer cells
With the cooler weather and frosts arriving, European wasp activity may decrease but the life of a queen is just beginning.
Frosts, along with continuous cold weather, trigger the release of up to 100 fertilised queens from European wasp nests. These queens could each establish new nests in the spring. By alerting the appropriate authorities and pest controllers to the presence of a nest, members of the publics can assist in reducing the numbers of this introduced pest.
In addition
The Robosoft company in Bidart (Lapurdi/Labourd) makes and markets robots that are programmed according to the requirements of the customer. These customised devices – robots – carry out numerous tasks that, in general, are laborious for us – lugging heavy loads around, cleaning chores, handling very small objects, and so on. The size and shape of each robot is distinct, according to the task(s) assigned it.
What is manufactured is a robot that is something like a train – it serves as a mean
EUREKA project E! 2427 PERMON is developing a radiological imaging system that will give medics a clearer view inside the human body by accurately monitoring organ blood flow during operations. This essential information will lead to an increase in techniques such as laser surgery over more invasive methods. Operations will be less costly and less traumatic to the patient, involving smaller incisions, less pain, and shorter hospital stays.
The project brought together a range of Polish and A
USC researchers provide unique view of inherited disorders, cancer with discussion of new field of epigenetics in journal Nature
Researchers from the USC/Norris Comprehensive Cancer Center are heralding an entirely new approach to the treatment of aging, inherited diseases and cancer in a review paper published in today’s issue of the journal Nature. Dispelling the belief that the only way to treat such conditions is by fixing or replacing damaged genes, they are instead focusing
Earthquakes not only shake up the local area but they also increase the rate of earthquake events locally and at a distance. The answer to how this happens may be in the laboratory, according to a Penn State researcher.
“We have learned a lot since the Landers earthquake in the Mojave Desert in 1992,” says Dr. Chris Marone, professor of geosciences. “We learned that earthquake triggering happens a lot more than we thought. The mechanism is not well understood.”
Marone is working wi
UCSF scientists are publishing sweet results of a study examining chocolate’s effects on blood vessel function in healthy people. The team reports that small daily doses of flavonoid-rich dark chocolate consumed over a two-week period improved blood vessels’ ability to dilate, or expand. They also report that a particular flavonoid thought to be beneficial for blood vessel function, epicatechin, was absorbed at high levels in the blood.
“This is the longest clinical trial to date to show i
Surprising find may be new genus
A team of American and Filipino biologists has discovered a new species –or perhaps a new genus – of mouse in the Philippines that took them quite by surprise.
The tiny mouse was captured on Mount Banahaw, a national park in the south-central portion of Luzon Island, only about 50 miles from Manila.
The bright-orange animal has a large head, heavily muscled jaws and powerful teeth that can open hard nuts. It weighs about 15 grams, a
Using a new computer model of the Sun, scientists have begun work on a groundbreaking forecast of the next cycle of sunspots. Mausumi Dikpati of the National Center for Atmospheric Research (NCAR) announced new research leading to an improved forecast of cycle 24 at the annual meeting of the American Astronomical Society (AAS) in Denver. Predicting features of the solar cycle may help society anticipate sunspots and associated solar storms, which can disrupt communications and power systems and exp
A new instrument developed at the National Center for Atmospheric Research (NCAR) has captured landmark imagery of fast-evolving magnetic structures in the solar atmosphere. Steven Tomczyk (NCAR High Altitude Observatory) presented the images on Monday, May 31, at the annual meeting of the American Astronomical Society (AAS) in Denver.
Animations from the coronal multichannel polarimeter, or CoMP, reveal turbulent, high-velocity magnetic features spewing outward from the Sun’s surface.
Two years after transforming human fat cells into what appeared to be nerve cells, a group led by Duke University Medical Center researchers has gone one step further by demonstrating that these new cells also appear to act like nerve cells.
The team said that the results of its latest experiments provide the most compelling scientific evidence to date that researchers will in the future be able to take cells from a practically limitless source — fat — and retrain them to differentiate al
Having lost ground to road transport in recent years, rail freight may be on the verge of making a comeback in Europe with the development of a wagon fleet management system that promises to increase efficiency, expand market potential and offer important benefits to society as a whole.
Due to begin trials this summer, the system developed by the IST project F-MAN offers fleet managers, railway companies and end customers with an integrated set of Web-based applications to trace wagons, man
Scientists from the University of Aberdeen, the Aberdeen-based Rowett Research Institute and the Medical Research Council (MRC) in Cambridge have made a major breakthrough in understanding how metabolism affects lifespan.
In a seven-year study of mice they found that those with the highest metabolic rate lived the longest, raising the prospect that the effect could be mimicked in humans.
Scientists have long thought that a high metabolic rate was linked to a shortened life-span. The
It is more convenient to glue parts together than to suture them. Even surgeons agree to that. They only need a good adhesive. Siberian researchers have created the third generation bio-adhesive and successfully tested it on animals.
Surgery is steadily improving methods for joining of slit parts. To solve the problem, biological adhesives were recently used. More often physicians use chemical compounds based on alpha cyanoacrylates, which do not provoke allergy or stimulate tumorogenesis. T
The Moscow radiochemists have developed and applied in practice new methods for analysis of transuranium elements in the environment objects. With the help of the most up-to-date techniques, they have investigated in detail the americium and plutonium migration paths in water and soils of some regions in Siberia and Southern Ural which are in particular need for such type of monitoring – in the vicinity of the Federal State Unitary Enterprise “Mayak” Manufacturing Company and Federal State Unitary En
The Day After Tomorrow – the latest Hollywood blockbuster movie released yesterday – depicts an extreme rapid climate change event following the sudden shutdown of the North Atlantic overturning circulation due to global warming. The film by Roland Emmerich, maker of ‘Independence Day’, is a dramatic portrayal of possible consequences of climate change.
Could this really happen?
The UK is taking the lead in rapid climate change research to try to answer that question. A
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