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Health & Medicine

Doctors Often Ignore Guidelines, Impacting Heart Patients

Heart failure patients who are treated in accordance with established European guidelines do better than patients who are not, yet many doctors are still not adhering to the guidelines, according to pioneering research published today (Tuesday 3 May) in Europe’s leading cardiology journal, the European Heart Journal.

In the first large European study to look at the effect of prescribing practices on outcome in heart failure outpatients outside of a clinical trial[1], Professo

Studies and Analyses

Study is first to implicate dietary fat in ’fatty liver’

A University of Minnesota study is the first to show that if you eat too much fat, it can go straight to your liver and damage it.

In obese people with nonalcoholic fatty liver disease (NAFLD), fat from the diet ends up “stuck” in the liver, where it doesn’t belong. It was known that the livers of NAFLD patients accumulated fat, but its origin was unknown. The new work implicates fat from the diet as one cause of NAFLD and shows that fat buildup in the liver results when the

Studies and Analyses

Low-Fat Diets: Why Quality Ingredients Matter for Heart Health

A low-fat diet rich in vegetables, fruits, whole grains and beans has twice the cholesterol-lowering power of a conventional low-fat diet, according to a new study from the Stanford University School of Medicine.

In other words, a meal of spinach salad, egg and oatmeal-carrot cookies is healthier for your heart than stir-fried lean beef and asparagus and low-fat chocolate chip cookies – even when both meals contain the same amount of saturated fat and cholesterol.

Th

Life & Chemistry

Heart Cells Induced to Multiply: A Breakthrough in Regeneration

Could lead to strategies to regenerate tissue after heart attack

In the best documented effort to date, researchers from the Howard Hughes Medical Institute at Children’s Hospital Boston and Harvard Medical School have successfully induced adult heart-muscle cells to divide and multiply.

Heart-muscle cells, or cardiomyocytes, were previously considered incapable of replicating in mammals after birth, which is why heart attack is such a problem: once killed, heart

Life & Chemistry

Unlocking Regeneration: Gene Insights from Planarian Worms

Although they may look small and unassuming, planarian worms are famous in the scientific world for their extraordinary ability to regenerate body parts after injury. Even a small piece cut off a planarian can reorganize and regenerate to form a whole new worm. Now, scientists have completed the first systematic investigation of gene function in planarians, opening the door to using genetic analysis to decipher how regeneration works in this enigmatic animal. The research, published in the May i

Life & Chemistry

Key Genes Regulate Human Blood Stem Cells in New Study

A study published in the May issue of Developmental Cell identifies specific genes that appear to be key players in the regulation of human-blood stem cells. This work is the first to validate gene expression analysis in human stem cells with functional experiments. The findings also suggest that changes in the expression of genes associated with universal cell signaling pathways can have a substantial impact on human stem cell behavior.

Formation and ongoing maintenance of bl

Health & Medicine

Boost Your Health: Full-Time Workers Need to Get Moving

Do you – like millions of full-time workers – surf TV channels, play video games or boot up the computer in what little free time you have? If so, there’s a good chance you’re skimping on heart-healthy physical activities, scientists report at the American Heart Association’s 45th Annual Conference on Cardiovascular Disease Epidemiology and Prevention.

In their study of nearly 4,500 men and women, a subset of full-time workers who spent more of their down time engaged in seden

Life & Chemistry

FGF-21: A Promising New Therapy for Type 2 Diabetes

Members of the fibroblast growth factor (FGF) family of proteins play many regulatory roles in several tissues. FGF-21 is a novel member of the FGF family, but its biological role was not known. In a study appearing online on May 2 in advance of the print publication of the June issue of the Journal of Clinical Investigation, Alexei Kharitonenkov and colleagues from Lilly Research Laboratories show that FGF-21 may be a new therapeutic treatment for Diabetes Mellitus.

The researchers show th

Health & Medicine

First Six Blind Patients Gain Vision with Artificial Retina

USC researchers present information on ’artificial retina’ May 2 at ARVO 2005

Researchers from the University of Southern California and the Doheny Eye Institute’s Doheny Retina Institute will be presenting data on the first six patients implanted with an intraocular retinal prosthesis-more popularly referred to as an artificial retina-developed and manufactured in partnership with Second Sight Medical Products, Inc., of Sylmar, Calif.

According to Mark Hum

Life & Chemistry

Hox Genes: Clustering Not Essential for Body Segment Function

The Hox genes (also known as homeotic genes) play a crucial role in the development of animals, being involved in the determination of segment identity along the body axis. These genes were discovered in the fruit fly Drosophila melanogaster 90 years ago and have been found later in all animals, including humans. The Hox genes are arranged in the fly genome in a striking manner: they are clustered and their order is the same as that of the body segments they act upon. This organization is conserved

Information Technology

Picture this – automatic image categorisation

Creating, storing and transmitting visual images has become increasingly easy. Yet the same problem always arises – how to categorise or classify visual images automatically without using external metadata or image thumbnails? There now may be an answer.

Researchers in the IST project LAVA have developed a method of automatically categorising the content of digital images, providing an effective means of storing and retrieving digital image content without having to rely

Earth Sciences

Envisat Aids Polar Challenge Racers to Magnetic North Pole

The final stretch of the Scott Dunn Polar Challenge is approaching: 44 competitors on 16 teams from all over Britain and Ireland are racing on skis, pulling sledges to the 500-kilometre-distant Magnetic North Pole. In this extreme environment, radar ice images from ESA’s Envisat help ensure competitors keep safe.

After a year in training, participants set up from Resolute Bay in Canada on Saturday 23 April – the start having been delayed a day by a blizzard. Expected to tak

Life & Chemistry

Regular Exercise Activates 500 Genes in Your Muscles

A new study from Karolinska Institutet in Stockholm shows that hundreds of genes in the thigh muscle are activated in regular cycle training. The study also reveals that great differences in training response may be due to the ability in some people to activate their genes much more forcefully. The study is published May 2 in FASEB Journal.

It is common knowledge that it is very dangerous to be inactive and that regular physical activity brings health, improves quality of life and extend

Life & Chemistry

Researchers discover genetic glitch in the heart’s electrical system

Mayo Clinic researchers have identified defects in a second gene called RyR2 that causes malfunctions in the heart’s electrical system and contributes to what were previously unexplained drownings.

Mayo researchers first discovered defects in a gene that causes the heart’s electrical system to malfunction and described how it might cause a drowning of an otherwise healthy person and reported their findings in a study published in the New England Journal of Medicine

Studies and Analyses

MPAA Ratings Misleading: Study Reveals Violence Discrepancies

What do the family film “The Jungle Book” and the action thriller “True Lies” have in common? Both contain similar amounts of violence despite respective PG and R ratings.

A new study led by researchers at the UCLA School of Public Health shows that parents and filmgoers who use the Motion Picture Association of America (MPAA) ratings system to gauge movie content receive little meaningful guidance related to violent content.

The study was funded by the Centers for Dise

Studies and Analyses

Patient Safety Gaps Widen Among U.S. Hospitals, Study Finds

– Three-Year Study Covers 37 Million Hospitalizations, Uses AHRQ Indicators –

– Nation’s Safest Hospitals, Identified in Study, Tend to Have “Culture of Safety” –

– Cost to Medicare of Patient Safety Incidents: $3 Billion Annually –

– Hospital-Acquired Infections Grow, Prove Costly –

Patient safety incidents at America’s hospitals increased slightly, but the nation’s safest hospitals grew even safer, resulting in a wider gap in patient safety inciden

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