Chicken-produced antibodies demonstrate enhanced cell killing compared to conventionally produced anti-cancer antibodies
Origen Therapeutics today announced the first published scientific report of fully functional, human sequence monoclonal antibodies (mAbs) produced in chickens. The antibodies were expressed solely in the chicken oviduct and deposited into egg white in concentrations of 1-3 milligrams per egg. Moreover, antibodies produced in this manner demonstrated 10-100 fo
Biochemical technique expected to yield new, more effective test for disease-causing prions in cattle and humans
Researchers at the University of Texas Medical Branch at Galveston (UTMB) have found a way to detect in blood the malformed proteins that cause “mad cow disease,” the first time such “prions” have been detected biochemically in blood.
The discovery, reported in an article scheduled to appear online in Nature Medicine Aug. 28, is expected to lead to a much more
Research teams at Nihon Nohyaku Co., Ltd., Bayer CropScience and DuPont have developed two new classes of broad-spectrum insecticides that show promise as a safer and more effective way to fight pest insects that damage food crops. The insecticides, which represent the first synthetic compounds designed to activate a novel insecticide target called the ryanodine receptor, may also help tackle the growing problem of insecticide resistance, the researchers say. They described their studies today
DNA isn’t just for storing genetic codes any more. Since DNA can polymerize — linking many molecules together into larger structures — scientists have been using it as a nanoscale building material, constructing geometric shapes and even working mechanical devices.
Now Cornell University researchers have made DNA buckyballs — tiny geodesic spheres that could be used for drug delivery and as containers for chemical reactions.
The term “buckyballs” has been used up to
Coffee provides more than just a morning jolt; that steaming cup of java is also the number one source of antioxidants in the U.S. diet, according to a new study by researchers at the University of Scranton (Pa.). Their study was described today at the 230th national meeting of the American Chemical Society, the world’s largest scientific society.
“Americans get more of their antioxidants from coffee than any other dietary source. Nothing else comes close,” says study leader
Engineers at Purdue University have developed a new way of producing hydrogen for fuel cells to automatically recharge batteries in portable electronics, such as notebook computers, and eliminate the need to use a wall outlet.
The findings will be presented Sunday (Aug. 28) during the annual meeting of the American Chemical Society in Washington, D.C., and also will be detailed in a peer-reviewed paper to appear in an upcoming issue of the journal Combustion and Flame. The pa
Brookhaven’s ’Electro Pen’ may impact a host of developing nanotechnologies
At the U.S. Department of Energy’s Brookhaven National Laboratory, scientists have developed a new chemical “writing” technique that can create lines of “ink” only a few tens of nanometers, or billionths of a meter, in width.
“Our new ’writing’ method opens up many new possibilities for creating nanoscale patterns and features on surfaces. This may have a significant
Chemists are several steps closer to teasing hydrogen fuel from water using man-made molecular devices that collect electrons and use them to split hydrogen from oxygen.
Virginia Tech graduate students in chemistry will present two posters at the 230th national meeting of the American Chemical Society in Washington, D.C., Aug. 28 through Sept. 1, 2005, describing photochemical processes.
Electrons are negatively charged particles that allow atoms to react and form bond
Chemistry and biology researchers at Virginia Tech have enhanced the abilities of the molecules they are creating to deliver killing blows to cancer cells. The man-made molecular complexes enter cancer cells and, when signaled, deliver killing medicine or cause the cell to change. The new supermolecules have more units that will absorb light – providing more control over the range of light frequencies that can be included and excluded as signals and the responses.
Karen Brewer, p
Results reported at American Chemical Society meeting
A chemical catalyst developed at Carnegie Mellon University completely destroys dangerous nitrophenols in laboratory tests, according to Arani Chanda, a doctoral student who is presenting his findings on Sunday, Aug. 28, at the 230th meeting of the American Chemical Society (ACS) in Washington, D.C. (Division of Industrial and Engineering Chemistry, Convention Center Hall A).
“We found an efficient, rapid and envi
For the first time, scientists have produced images of the oceanic crust and found that the upper and lower layers of the crust are likely formed from different magma pools. The images begin to answer some lingering questions about where new ocean crust comes from and whether it is all formed the same way.
Geophysicists Robert Detrick and Juan-Pablo Canales of Woods Hole Oceanographic Institution (WHOI) and colleagues used reflected seismic, or sound, waves to successfully image t
Inhibitory systems are essential for controlling the pattern of activity in the cortex, which has important implications for the mechanisms of cortical operation, according to a Yale School of Medicine study in Neuron.
The findings demonstrate the inhibitory network is central to controlling not only the amplitude, extent and duration of activation of recurrent excitatory cortical networks, but also the precise timing of action potentials, and, thus, network synchronization, s
The heart-lung bypass machine that stills the heart while surgeons bypass an adult’s clogged arteries or repair a baby’s malformed heart can also trigger a potentially deadly inflammatory response.
That unfortunate fact has Medical College of Georgia surgeons participating in an international study of a drug that may block the most deadly of these responses in adults who have coronary bypass surgery.
It also has them trying to better understand the process in children who
Researchers at Duke University Medical Center have identified a previously unknown family of virulence factors that make the bacterium responsible for the plague especially efficient at killing its host.
In the process, the team not only demonstrated that the use of the common roundworm is a valid model for studying the virulence of Yersinia pestis, the bacterium that causes plague. They also showed that the interaction between Y. pestis and the worm is quite similar to what occur
Long-term hormone therapy used earlier in menopause is associated with fewer wrinkles and less skin rigidity in postmenopausal women, Yale School of Medicine researchers report in the August issue of Fertility and Sterility.
“These benefits were seen in women who had consistently used hormone therapy and had been in menopause for at least five years,” said Hugh S. Taylor, M.D., associate professor in the Division of Reproductive Endocrinology and Infertility in the Department of Ob
How germ cells decide whether to be sperm or eggs
Johns Hopkins biologists have determined how developing embryos tell their specialized “germ cells” whether to develop into a male’s sperm or a female’s eggs.
Present in both male and female embryos, germ cells are the precursors to both sperm and eggs. Unable to “decide” on their own which to become, however, germ cells must take “advice” from other cells within embryos as to which is the appropriate sex. The Johns Hop
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