A new type of targeting chaperon protein HSP70 inhibitor QL47 was recently discovered by a team led by Prof. LIU Qingsong from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences to treat FLT3-ITD-positive acute myeloid leukemia (AML). Their findings have been published on Signal Transduction and Targeted Therapy. “What we are seeking is a new therapeutic strategy which imperative for FLT3-ITD-positive AML,” said HU Chen, lead author of the study. Approximately, 25% of AMLs carry FLT3-ITD (internal…
Scientists develop new computational method that can simulate hydrogen storage on silicon carbide nanotubes much more accurately than conventional method. Hydrogen energy has the potential to be a key measure to meet the United Nations net zero emissions target, but its industrial use has been hindered by the difficulty in its storage and handling. Hydrogen becomes a gas at a very low temperature (-252°C), which makes its storage at room temperature challenging. The interaction between hydrogen and its storage material…
Controlling the structure of fragmented electrodes composed of carbon nanotubes could offer improved wireless monitoring of the strain on materials in a wide range of applications. “This opens endless possibilities for every situation where accurate wireless monitoring of structures is important,” says Gilles Lubineau, Professor of Mechanical Engineering at KAUST. Lubineau developed the technology with postdoc Hussein Nesser, who adds: “Our sensor can directly be used to assess, in-situ and with great accuracy, the strain exerted on materials.” Monitoring the strains…
The “North Sea Wrecks” team from the German Maritime Museum (DSM) / Leibniz Institute for Maritime History in Bremerhaven was on another research trip in the North Sea. Thanks to technical support from the German Aerospace Center (DLR), detailed images of four wrecks were obtained. They were at sea again: the researchers from the North Sea Wrecks (NSW) project, who are investigating the dangers posed by old World War II munitions at the bottom of the North Sea and the…
How resilient is our food supply? Temporarily empty shelves during the Corona crisis showed that the answer to this question is more urgent than ever. Guaranteeing people a supply of food that is both safe in terms of health and of high quality is an essential system-relevant tasks that is affected by complex factors and that needs to be rethought in many respects in view of several weaknesses in the system. Researchers from six Fraunhofer-Gesellschaft Institutes have set themselves this…
This technology will give researchers insight into how the nervous system works and the chance to develop new ways of treating neurological disorders. Grégoire Courtine doesn’t hesitate to use the word “revolutionary” when describing the emerging field of optogenetics – a technology that uses pulses of light to control individual neural activity – and what it could mean for neuroscience. Courtine, director of the NeuroRestore research center (with neurosurgeon Jocelyne Bloch), is currently developing an optogenetic implant together with Stéphanie…
Like the speed of an advancing race car driver, the winds in the outermost “lane” of Jupiter’s Great Red Spot are accelerating – a discovery only made possible by NASA’s Hubble Space Telescope, which has monitored the planet for more than a decade. Researchers analyzing Hubble’s regular “storm reports” found that the average wind speed just within the boundaries of the storm, known as a high-speed ring, has increased by up to 8 percent from 2009 to 2020. In contrast,…
… a phenomenon finally understood. Like a work of art enshrined in a museum, some stones end up on a pedestal of ice in nature, with no human intervention. This “Zen stone” phenomenon, named after the stacked stones in Japanese gardens, appears on the surface of frozen lakes, Lake Baikal (Russia) in particular. These structures result from the phenomenon of sublimation, which causes a body, in this case ice, to change from solid to gaseous form without the intermediary form…
Researchers from Chalmers University of Technology, Sweden, have succeeded in creating tiny vehicles powered by nothing but light. By layering an optical metasurface onto a microscopic particle, and then using a light source to control it, they succeeded in moving the tiny vehicles in a variety of complex and precise ways – and even using them to transport other objects. WATCH A VIDEO OF THE METAVEHICLES IN ACTION HERE Light has an inherent power to move microscopic objects –…
Different forms of linear transformations, such as the Fourier transform, are widely employed in processing of information in various applications. These transformations are generally implemented in the digital domain using electronic processors, and their computation speed is limited with the capacity of the electronic chip being used, which sets a bottleneck as the data and image size get large. A remedy of this problem might be to replace digital processors with optical counterparts and use light to process information. In…
Insight into the molecular structure of an appetite-regulating cell receptor A protein – measuring just a few nanometers in size – acts as a molecular switch with a crucial role in determining whether we feel hungry or full. By determining of the protein’s 3D structure, researchers from Charité – Universitätsmedizin Berlin were able to visualize the molecular structures of the hormones with which this protein – melanocortin 4 receptor (MC4R) – interacts. Writing in Cell Research*, the researchers report that…
Researchers in Bayreuth discover novel sensors. Due to their iridescent colors, opals have been considered particularly precious gemstones since antiquity. The way these stones shimmer is caused by their nanostructures. A research group led by Prof. Dr. Markus Retsch at the University of Bayreuth has produced colloidal crystals mimicking such structures, which are suitable for constructing new types of sensors. These sensors visibly and continuously document the temperature in their environment during a defined period. They are, therefore, tailor-made for…
In a new publication from Opto-Electronic Advances; DOI 10.29026/oea.2021.200064, Researchers led by Professor Xu Chunxiang, Southeast University, Nanjing, China discuss nano-buffer controlled electron tunneling to regulate heterojunctional interface emission. Light emitting diodes (LEDs) are widely used in the field of lighting and display. Homojunction is the best choice when considering interface loss and carrier concentration matching. However, for some semiconductor materials, where it is difficult to obtain homojunction, energy level matching heterostructure is also a choice to build LEDs. Compared with…
The Universe is filled with energetic particles, such as X rays, gamma rays, and neutrinos. However, most of the high-energy cosmic particles’ origins remain unexplained. Now, an international research team has proposed a scenario that explains these; black holes with low activity act as major factories of high-energy cosmic particles. Details of their research were published in the journal Nature Communications. Gamma rays are high-energy photons that are many orders of magnitude more energetic than visible light. Space satellites have…
This sparkling starfield, captured by the NASA/ESA Hubble Space Telescope’s Wide Field Camera 3 and Advanced Camera for Surveys, contains the globular cluster ESO 520-21 (also known as Palomar 6). A densely packed, roughly spherical collection of stars, it lies close to the center of the Milky Way, where interstellar gas and dust absorb starlight and make observations more challenging. Interstellar absorption affects some wavelengths of light more than others, changing the colors of astronomical objects by causing them to…
Stanford University and the University of North Carolina Chapel Hill develop microneedle vaccine patch that outperforms needle jab to boost immunity. Scientists at Stanford University and the University of North Carolina at Chapel Hill have created a 3D-printed vaccine patch that provides greater protection than a typical vaccine shot. The trick is applying the vaccine patch directly to the skin, which is full of immune cells that vaccines target. The resulting immune response from the vaccine patch was 10 times…
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