A study led by researchers from the Howard Hughes Medical Institute has found that dasatinib provides significant benefit in chronic myeloid leukemia (CML) patients resistant to Gleevec® (imatinib), according to a study presented today during the 97th Annual Meeting of the American Association for Cancer Research.
In an update of a phase I study initiated in November 2003, researchers looked at the use of dasatinib in imatinib resistant or intolerant patients with CML in late chr
The purity of birdsong is owed in large part to rapid, controlled changes in the shape of the birds’ upper vocal tracts, according to a new study of Northern Cardinals by scientists at Indiana University Bloomington, Purdue University and Australian National University. Their report will appear in next week’s (April 4) Proceedings of the National Academy of Sciences.
“We show that songbirds adjust the size and shape of their vocal tract to ’fit’ the changing frequency of their song,
Scientists discover structure of defense process, how to inhibit it
Scientists from two universities in Italy and Virginia Tech in the United States have determined the structure of a protein that is responsible for the production xanthurenic acid (XA) in Anopheles gambiae, the malaria carrying mosquitoes. XA plays a key role in the sexual reproduction of the malaria parasite (Plasmodium falciparum) in A. gambiae mosquitoes. Interfering with the formation of XA could be an avenue for
In a paper being presented in two American Physiological Society sessions at Experimental Biology 2006, a joint Estonian-French team demonstrated “for the first time that mitochondria are able to induce nuclear deformation, suggesting that mitochondria may mechanically regulate nuclear function.”
The team, which has been collaborating for over 10 years, reported that it recently “found a very interesting and unexpected phenomenon: various substances which increase mitochondrial s
Industry board issues ratings without playing games
According to a study led by Associate Professor Kimberly Thompson of the Kids Risk Project at Harvard School of Public Health (HSPH), 81% of a random sample of Mature-rated video games included content that was not noted on the game box. This is the first independent, quantitative study to characterize content in M-rated games related to violence, blood, sexual themes, substances, profanity, and gambling observed in game play.
Findings May Offer Therapeutic Potential for Sepsis Treatment
Disruption of a single gene, Nrf2, plays a critical role in regulating the body’s innate immune response to sepsis and septic shock, according to a study by a research team led by Shyam Biswal, PhD, at the Johns Hopkins Bloomberg School of Public Health. The researchers found that the absence of Nrf2 caused a dramatic increase in mortality due to septic shock in mice. The study’s findings, which will be published in the A
Astronomers from the University of Nottingham, UK, and the Instituto de Astrofisica de Canarias (Spain), have found the first observational evidence that galaxies are not randomly oriented.
Instead, they are aligned following a characteristic pattern dictated by the large-scale structure of the invisible dark matter that surrounds them.
This discovery confirms one of the fundamental aspects of galaxy formation theory and implies a direct link between the global proper
Mango is one of the most widely grown fruit trees in Burkina Faso, with national output running at around 50 000 tonnes/year. Fresh Burkinese mangoes face strong competition on the export market from mangoes from Mali and Ivory Coast. To use up the resulting production surplus, cut fruit losses and gain access to new markets, the first drying units were set up in Burkina Faso in 1980, with the support of the authorities and NGOs. The country’s dried mango sector now concerns around fifty small
UK astronomers have been at the forefront of designing a revolutionary new X-ray telescope that is based on the eyes of a lobster. By replicating the crustacean’s ability to observe objects all around it without turning its head, scientists are confident that the Lobster instrument will enable a major breakthrough in X-ray astronomy.
The sky viewed at X-ray wavelengths is a violent and unpredictable place. Many sources brighten without warning, then vanish just as suddenly. Oth
COST (European Cooperation in Science and Technology) is launching an Open Call for proposals.
COST invites researchers throughout Europe to submit proposals for research networks and use this unique opportunity to exchange knowledge and to embark on new European perspectives.
COST’s main objective is to stimulate new, innovative and interdisciplinary scientific networks in Europe. COST activities (Actions) are carried out by research teams to strengthen the foundations
For scientists a good publication record is a recipe for success, and it’s never too early to start. Dr Celia Knight (University of Leeds) has established ‘Biolog-e’ – a web-based journal which publishes first class biology research projects. And the students love it! “They can show their friends, families and future-employers evidence of skills in science research and communication”, says Dr Knight who will be presenting the project at the Society for Experimental Biology Main Meeting in Canter
If a large asteroid such as the recently identified 2004 VD17 – about 500 m in diameter with a mass of nearly 1000 million tonnes – collides with the Earth it could spell disaster for much of our planet. As part of ESA’s Near-Earth Object deflecting mission Don Quijote, three teams of European industries are now carrying out studies on how to prevent this.
ESA has been addressing the problem of how to prevent large Near-Earth Objects (NEOs) from colliding with the Earth for some
EUREKA project E! 1493 ULTIMATE has led to the development of a highly sophisticated simulator to improve car design and increase road safety in Europe using novel mechanical, display and software technology.
Simulators can make a major contribution to vehicle design and the study of human driving factors. However, they have been of more limited value for road vehicles due to the large linear motion needed (for e.g. when turning corners or during braking). As a result, the cost o
Large quantities of Saharan dust are helping to fertilize the massive plankton blooms that occur in the tropical eastern Atlantic, a research project has confirmed.
A team including researchers from the School of Environmental Sciences at the University of East Anglia has been studying the desert dust, which is rich in nitrogen, iron and phosphorus, and its effect on the ocean’s nutrients, plankton production and the food chain.
The £600,000 project, is part of the Sur
The number of older people living in the English countryside is soaring at a much faster rate than the rest of the country, posing numerous urgent challenges to the Government and other bodies.
Researchers from the University of Newcastle upon Tyne and other leading experts will highlight the statistics and issues they provoke at a conference in York today, Tuesday April 4.
Figures show that 5.3m of England’s projected 5.5m population growth in the period until 2028 w
The European Space Agency’s XMM-Newton X-ray observatory has already been a spectacular success in many areas of astronomy – detecting distant clusters of galaxies, the faint afterglow of enigmatic gamma ray bursts and the effects of the collision of the Deep Impact probe with comet Tempel-1.
Now an innovative new approach analyses X-rays detected during the times that the satellite manoeuvres between targets – originally considered to be unusable periods – to reveal some 4,000 i
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