Research led by Cincinnati Children’s suggests potential applications beyond blood cancers. Research led by experts at Cincinnati Children’s has revealed a protein—UBE2N—that appears crucial to multiple pathways that contribute to acute myeloid leukemia (AML) cell survival. The team also has found a class of small molecules that block the protein’s function, which in turn kills AML cells in lab dishes and in mouse models—without killing healthy blood cells. This potential breakthrough toward developing a novel therapy for AML was published…
Assay can quickly and easily inform decisions about public health policy and treatment for individual patients and can rapidly detect new variants, such as omicron, investigators report in The Journal of Molecular Diagnostics. After the start of the SARS-C0V-2 pandemic, investigators from ResearchPath LLC and their collaborators at Rutgers University quickly dedicated resources to develop accurate and reliable COVID-19 testing. As variants emerged, they developed a PCR test that uses molecular beacons not only to diagnose COVID-19 infection, but also…
Fragments of the interior of a proton have been shown by scientists from Mexico and Poland to exhibit maximum quantum entanglement. The discovery, already confronted with experimental data, allows us to suppose that in some respects the physics of the inside of a proton may have much in common not only with well-known thermodynamic phenomena, but even with the physics of… black holes. Various fragments of the inside of a proton must be maximally entangled with each other, otherwise theoretical predictions would…
Runoff in coastal waters is linked to pollution and degradation of coral reefs and other marine ecosystems. Unmanned aerial vehicles (UAVs) have now been used to overcome the challenges of monitoring water flow between ecosystems and over large areas. High-frequency hovering UAV images and flight surveys were used by KAUST researchers to track the movement of dye plumes released during an ebbing tide. Led by remote sensing researcher Kasper Johansen, the team also used information from aerial images combined with…
When our immune system comes into contact with SARS-CoV-2, it fights back and produces antibodies. A similar immune response is triggered by Corona vaccines. However, there is still little data available on the strength and durability of immune protection. A team led by Prof. Carsten Watzl from the IfADo, in cooperation with the Max Planck Institute oin Dortmund (MPI) and the Klinikum Dortmund, has now been able to detect high levels of neutralising antibodies in test persons even 300 days…
A convenient and powerful tool in neuronal research. Toyohashi University of Technology research team led by Prof. Rika Numano and Prof. Takeshi Kawano showed DNA stamper injections can be performed delivering biomolecules into live neuronal cells within brain tissues ex vivo and in vivo using nanoscale-tipped wire (NTW) arrays to genetically modify and restore cell function in the brain. These NTW array injections followed the exploration of pacemaker cells in the brain slice of central clock with knockdown function using…
Fix in a manufacturing step of perovskite solar cells paves the way for commercialization of the high-performance, sunlight-to-electricity discovery. Materials scientists at the UCLA Samueli School of Engineering and colleagues from five other universities around the world have discovered the major reason why perovskite solar cells — which show great promise for improved energy-conversion efficiency — degrade in sunlight, causing their performance to suffer over time. The team successfully demonstrated a simple manufacturing adjustment to fix the cause of the…
The flexible backing allows arrays of micro-scale needles to conform to the contours of the brain, which improves high-resolution brain recording. Engineering researchers have invented an advanced brain-computer interface with a flexible and moldable backing and penetrating microneedles. Adding a flexible backing to this kind of brain-computer interface allows the device to more evenly conform to the brain’s complex curved surface and to more uniformly distribute the microneedles that pierce the cortex. The microneedles, which are 10 times thinner than…
Chemists have developed a nano-scale structure that combines copper, gold and silver to work as a superior catalyst in a chemical reaction whose improved performance will be essential if carbon capture and utilization efforts are to succeed in helping to mitigate global warming. A study describing the process appeared in the journal Nano Research on Mar. 15. In the face of the climate change challenge, in recent years, policy-makers have increasingly focused on carbon-capture-and-utilization (CCU), wherein CO2 is drawn down from the…
Researchers have developed a new method to display highly realistic holographic images using ‘holobricks’ that can be stacked together to generate large-scale holograms. The researchers, from the University of Cambridge and Disney Research, developed a holobrick proof-of-concept, which can tile holograms together to form a large seamless 3D image. This is the first time this technology has been demonstrated and opens the door for scalable holographic 3D displays. The results are reported in the journal Light: Science & Applications. As…
Energy and resource efficiency are gaining ever more significance, which is why the Fraunhofer IWS has worked with partners to develop an alternative for conventional steel construction that not only constitutes a process technology solution, but also forms the basis for hardware and laser safety. This solution facilitates gentler machining of high-strength materials, as well as significantly reducing energy consumption and costs while greatly increasing process speed. The energy in-put required for the component can be reduced by up to…
Study shows how the mechanism of photoionization can be used to gain insights into complex molecular potentials. How can researchers use the mechanism of photoionization to gain insight into complex molecular potential? This question has now been answered by a team led by Prof. Dr. Giuseppe Sansone from the Institute of Physics at the University of Freiburg. The researchers from Freiburg, the Max Planck Institute for Nuclear Physics in Heidelberg and groups at the Universidad Autonoma in Madrid/Spain and the…
Semiconductors are the foundation of modern technology while superconductors with their zero electrical resistance could become the basis for future technologies, including quantum computers. So-called “hybrid structures” – carefully crafted sandwiches made from superconductors and semiconductors – may lead to new quantum effects. However, convincing observations have remained elusive. Now, researchers at Institute of Science and Technology Austria (ISTA) with NYU collaborators found a way to probe such “super-semi sandwiches” and to reveal what is going on. “There is an…
A living cell is exposed to a variety of stimuli. Countless messengers dock on its surface, where receptors in the cell membrane receive the incoming “orders.” Signaling cascades are then triggered inside the cell, which ultimately responds by producing or breaking down substances, or by switching genes on and off in the cell nucleus. So far so clear. But what’s exactly going on here? Researchers at the Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) have now…
Capturing transparent objects in three dimensions is a major challenge. Researchers at Fraunhofer Institute for Applied Optics and Precision Engineering IOF have developed a sensor that is able to solve this problem. The system has now been successfully tested for the first time with a robot. Applications in large-scale industrial manufacturing processes such as the semiconductor or automotive industry could be possible. The sensor will be featured at the Hannover Messe Preview on March 16 and at the German trade…
Increasing lifetime and safety, decreasing maintenance and power generation costs and CO2 emission: That is the goal of a research project involving U Bremen Research Alliance member institutions. Researchers from the Leibniz Institute for Materials Engineering – IWT and the Fraunhofer Institute for Wind Energy Systems IWES are focusing on a component of wind turbines that has to withstand a great deal: the rotor blade bearing. She has a natural preference for steel, says Brigitte Clausen. What fascinates her so…
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