It was surprisingly found that the pyridinylidene hydrazone derivatives inhibit AChE and BuChE as well as Aβ fibril formation significantly. They can destroy…
The treatment of IP-10 mediated inflammatory diseases, especially inflammatory bowel diseases, is hampered by lack of treatment effects in some patients and a…
Proteins of the Lancefield group A haemolytic streptococci (Streptococcus pyogenes) share amino-acid sequence homologies with various human proteins. As a…
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that attacks the joints producing an inflammatory synovitis. Current treatment options…
The following invention is a new, peptide based vaccination against genetical stable tumor stroma-associated antigens. Because of significant upregulation of…
Pathogenic microbes possess sophisticated molecular tools to suppress the immune response of their mammalian hosts. Recently, a novel mechanism used by…
Cardiovascular diseases, cancers, immune diseases and mental development of children are related to the fatty acid composition of circulating lipids and…
Magnetic nanoparticles provide a multitude of technical applications like magnetic resonance imaging, hyperthermic treatment of cancer, drug delivery,…
Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and prion diseases share molecular mechanisms including protein aggregation and…
Apoptosis is a highly conserved process regulating the balance between cell death and proliferation for the maintenance of tissue homeostasis. Inhibitor of…
Cataract is the leading cause of preventable blindness in elderly or diabetic patients worldwide. With a simple surgical technique, the opaque lens can be…
Solubilization of hydrophobic drugs is a key issue in pharmaceutical industry. Currently, there are few non-toxic formulations available for drugs like…
Thermostable, fast-folding esterase 2 from Alicyclobacillus acidocaldarius serves as a reporter enzyme to monitor in vivo or in vitro expression of eukaryotic…
Neuropathic pain is rather resistant
to conventional analgesics. Therefore,
different approaches must be
taken to treat neuropathic pain. One
…
The invention is a lipid based implant, produced by screw extrusion. To achieve good extrudability, very homogeneous drug distribution, excellent mechanical…
The invention is a lipid based delivery systems based on a vesicular phospholipid gel (VPG) formulation comprising tightly packed liposomes. Protein…
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