Vascular disrupting agents (VDA) can overcome the multidrug resistance of tumors by targeting specifically tumor vasculature. The present invention relates to specific analogs of combretastatin in the treatment or prevention of cancer, including multidrug-resistant and combretastatin-refractory cancers.
Developmental Status: Pharmacodynamical and toxicological studies currently in the works , Animal data available, Further mouse studies on tumor xenografts from other entities planned, Compound samples available for testing
The invention relates to a new process for the continuous production of glycerol-tertiary-butyl-ether (GTBE) by
etherification of glycerol and isobutene.
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