Tool coils for or magneforming (or electromagnetic forming = EMF) of complex, 3D shaped parts were previously wound from wires or produced by complex
processes such as milling and wire eroding. The milling process is necessary to produce the outer contour. Wire eroding is used to create the winding structures,
whereby it should be noted, that a 3D design is very limited. The invention concerns to special coils
for EM forming and for a method for their production, wherein the current-carrying coil body is additively manufactured using a rapid prototyping method (laser
melting, etc.).
Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by the deficiency of arylsulfatase A (ASA). This results in accumulation of sulfated glycosphingolipids, mainly 3-O-sulfogalactosylceramide (sulfatide), in the nervous system and various other organs. In patients, lipid storage causes a progressive loss of myelin leading to various neurological symptoms. The sulfatide storage in ASA-deficient mice is comparable to humans, but the mice do not mimic the myelin pathology.
Therefore, transgenic ASA-deficient (tg/ASA(-/-)) mice were generated overexpressing the sulfatide-synthesizing enzyme galactose-3-O-sulfotransferase.
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