A Cornell cancer research team is taking a new approach to screening for these dangerous cells, using a microfluidic device they invented that isolates only…
A group of astronomers led by Dr. Santiago Vargas Domínguez has analyzed the highest- resolution solar observations ever made. A summary of their work at BBSO…
On the commercial front, Target suffered the largest retail hack in U.S. history during the Christmas shopping season of 2013, and now the Fortune 500…
The study, published today (Wednesday 4th June 2014) in the Journal of Animal Ecology, shows that tree bumblebees have rapidly spread despite them carrying…
More than 365 decision-makers from the banking sector took part in the Bank & Zukunft 2014 trend survey. In rating current challenges and developments, their…
However, statisticians headed by Achim Zeileis from the University of Innsbruck show that the winning margin is considerably higher for Brazil than generally…
The Federal Statistical Office (Destatis) also reports that their number rose by 1% compared with the previous winter semester.
Early in their development, these larvae swim towards the light to use surface currents for their dispersal. Older larvae turn away from the light and swim to…
Adenosine is a modulator of many physiological and pathophysiological processes in the central nervous system (CNS). Blockade of the adenosine receptors A1ARs and A2AARs has shown beneficial neuroprotective effects in animal models and in clinical studies of Parkinsons’s disease (PD) and Alzheimer’s disease (AD). There is still no satisfactory multitarget drug approach which inhibits MAO-A and the two adenosine receptors A1ARs and A2AARs. This invention provides newly designed tricyclic xanthine derivatives which allow overcoming this problem. A variety of 69 derivatives were prepared and evaluated in radioligand binding studies at adenosine receptors and for their ability to inhibit monoamine oxidases. Potent dual-target-directed A1/A2A adenosine receptor antagonists were identified. Several compounds even showed triple-target inhibition.
One of the turbines will be used in a fertilizer factory in Indonesia's East Java province, delivering an electrical generating capacity of 12 megawatts (MW)….
Researchers from the University of Twente in the Netherlands have taken the precise art of origami down to the microscopic scale. Using only a drop of water,…
Hydrogen is often touted as the fuel of the future. But because this gas is highly explosive, it must be stored and transported under pressure in specialized…
Enjoying the landscape when traveling by train—while this activity sounds like pure relaxation, in reality, it requires maximum performance of our eyes’ motor…
Duke researchers have found a new type of neuron in the adult brain that is capable of telling stem cells to make more new neurons. Though the experiments are…
As a counter to this time-consuming and substantial scientific effort, there are a number of examples of protein crystallization events occurring in vivo, with…
The rates of community-onset methicillin-resistant Staphylococcus aureus (CO-MRSA) varied dramatically among academic medical centers in California, New York,…
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