The researcher has concluded that walls comprising plants offer great potential for absorbing noise and could be used as acoustic insulation. Right now, she is…
The technology developed by Marco Adame, founder of Ak Inovex, can process more than 90 percent of any type of plastic, avoids water waste and reduces…
Overweight is associated with problems in sugar and lipid metabolism as well as with atherosclerosis, and these may be caused by a low-grade inflammatory state…
Plant geneticists including Sam Hazen at the University of Massachusetts Amherst and Siobhan Brady at the University of California, Davis, have sorted out the…
When University of Utah biologists fed mice sugar in doses proportional to what many people eat, the fructose-glucose mixture found in high-fructose corn syrup…
How and why these invertebrates produce their spectacular display is a mystery. New research by Lindsey Dougherty of the University of California, Berkeley,…
University of California, Santa Barbara, PhD student Emily Ellis and her colleagues in the laboratory of Dr. Todd Oakley are interested in the evolution of…
Groups at the Weizmann Institute of Science and Cambridge University have jointly managed the feat of turning back the clock on human cells to create…
A group of scientists led by researchers at the Université de Versailles' Institut Lavoisier in France has worked out how to stably gift-wrap a chemical gas…
The findings, published this week in the Proceedings of the National Academy of Sciences, could be relevant to understanding and perhaps controlling oxidation…
In the race to design the world's first universal quantum computer, a special kind of diamond defect called a nitrogen vacancy (NV) center is playing a big…
Results from a study published on Jan. 2 in Science defy textbook science, showing for the first time that the building blocks of a protein, called amino…
The present technology provides 3'-photolabile nucleoside derivatives for producing nucleotides. The resulting oligonucleotides built up on the support by light-controlled synthesis are linked to the solid phase via the 5' end and thus can be used for investigating reactions that require free 3'-OH ends, for example certain DNA-enzyme interactions.
New method for producing a highly diverse antibody library, where pro-teins/antibodies can be selected for specific applications. A large and, compared from cell to cell, highly uniform number of antibodies is covalently attached to the surface of a eukaryotic cell. Using this technology, specific antibodies can be selected together with the presenting cell out of a high number of cells in a comparatively easy way. The technology can also be used humanizing a hybridoma cell line by enabling the homologous recombination of the constant do-mains of human immunoglobulins with the respective gene.
Optical fluorescence and gamma-labeled radio-pharmaceutical imaging offer complementary ways of probing and assessing the physiology of small animals. With the increasing use of both methods for functional molecular imaging in small animal models for applications such as cancer research and drug development, it has become more important to integrate their results, particularly for studies of the same animal. This can be performed through image registration of separate studies or through simultaneous tomographic acquisition with implicit registration of the two imaging modalities. DKFZ developed an optical imaging detector for fluorescence and bioluminescence in small animal imaging, which is compatible for single-photon emission computed tomography (SPECT).
The site-directed modification of e.g. biomolecules is often time consuming and laborious. This invention provides a high yielding and highly specific method to link nearly any molecule to nearly any other molecule. The “Click reaction” used is the well known Diels-Alder reaction with inverse electron demand. In this fast reaction an appropriate, easily functionalized dien (e.g. Tetrazin) is reacted with an appropriate functionalized dienophil (e.g. Olefin) to yield the conjugate. The release of nitrogen makes the reaction irreversible. No side reactions occur. Further the Intellectual Property covers specific information regarding the ligation of a diagnostic marker AND a therapeutic agent AND a biomolecule. Convincing synthetic data are available for the ligation of peptide with peptide, peptide with marker molecule, peptide with therapeutic agent, peptide with oligo nucleotide, dendritic structure and specific surface modification by means of this technology.
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