The function of brain macrophages is controlled by metabolites of gut bacteria, called short-chain fatty acids. Mice without gut bacteria developed stunted…
Scientists from Goethe University of Frankfurt am Main have identified serum biomarkers that differentiate patients with hepatocellular carcinoma (HCC) from those with liver cirrhosis. The identified sphingolipid metabolites C16-ceramide and sphingosine-1-phosphate (S1P) provide an extraordinary high diagnostic accuracy (AUC value > 0.98). Current HCC tests measure levels of alpha-fetoprotein (AFP) which show a significantly lower diagnostic performance.
According to the invention the approach of an easy risk assessment of patients with diagnosed cardiac insufficiency is based on the measurement of concentration of a pro-tein in whole blood called MD-2 by using the ELISA-technology. ELISA (Enzyme-Linked-Immunosorbent-Assay) is a common and standardized immunological assay for the detection of specific molecules in body liq-uids. It is well known that for cardiac degen-eration the activation of toll-like receptor-4 (TLR 4) is important. TLR 4 and MD-2 then form a receptor complex.
By the additional use of MD-2 biomarker to the “gold-standard” biomarker BNP for risk stratification of cardiac insufficiency, an in-crease of sensitivity and specificity regarding to the long-term survival can be realized. The used biomarker for this assay, is a MD-2 protein (also called LY96) which relates to the group of so-called “Immune response receptors”.
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University of Houston researchers have identified a new, less-invasive method to provide diagnostic information on kidney disease and its severity.
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These proteins could have a role in disease processes affecting the eye and serve as valuable biomarkers for the development of diagnostics and drug candidates…
At a traditional stone-laying ceremony outside La Serena, Chile on April 14th, construction officially began of the Large Synoptic Survey Telescope (LSST)….
“We have developed a 'designer carbon' that is both versatile and controllable,” said Zhenan Bao, the senior author of the study and a professor of chemical…
“I am extremely proud to announce the introduction of our new 7 Tesla scanner Magnetom Terra (1). It is the first 7 Tesla MRI scanner fully designed and…
Tropical storm Andres became the first tropical storm of the 2015 Eastern Pacific hurricane season on May 28 at 1500 UTC (11 a.m. EDT). The GPM core…
A patient tormented by suicidal thoughts gives his psychiatrist a few strands of his hair. She derives stem cells from them to grow budding brain tissue…
Male moths locate females by navigating along the latter's pheromone (odor) plume, often flying hundreds of meters to do so. Two strategies are involved to…
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