USE OF ERYTHROPOIETIN FOR THE TREATMENT OF
FRIEDREICH´S ATAXIA:
In addition to its neuro- and cardioprotective properties recombinant human erythropoietin (rhuEPO) significantly increases frataxin expression in primary lymphocytes from FApatients, and other cell types like neurons and primary human cardiac cells in vitro. (Sturm et.al 2005, Eur. J.Clin. Invest. 35(11):711-7) rhuEPO was successfully tested as a treatment for Friedreich`s ataxia in Phase IIa/IIb and dosefinding studies.
The present invention specifically provides a novel vaccine formulation
suitable for ocular immunization and provides a method for inducing a local and systemic immune response. The combination of the three components antigen & corpusculate bodies (eg.Bortedella pertussis (wBP)) & adjuvans showed the highest rise in IgA antibody titers in tears and sera when compared to other immunization groups. Immunization via the conjunctiva with TTd plus wBP and adjuvant resulted in a 33% survival rate of challenged mice compared to a 0% survival rate in non-immunized animals.
We have developed a new method for improvement of cellulase and hemicellulase production in Trichoderma reesei by overexpression of a developmental regulator.
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There is currently a strongly growing need for methods and chemicals for the preparation of large biological samples for three-dimensional imaging. The invented substance and protocol are of high interest for any supplier or company in the field of microscopy and imaging techniques. The unique selling proposition is that the herewith offered invention constitutes the sole methodology optical clearing of biological samples without use of harmful chemicals combined with high quality fluorescence preservation. The invented substance and protocol is routinely used by the inventors and has thus been shown to be robust for general laboratory usage.
On behalf of the University of Duisburg and Essen, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development, e.g. of a kit. In case of interest we will be pleased to inform you about the patent status.
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