The major clinical challenge in treating NPM-ALK+ anaplastic large cell
lymphomas (ALCL) is its high rate of relapse. Researchers of the Medical
University of Vienna identified high expression of PDGFRß in the NPMALK
induced ALCL. Pharmaceutical targeting of PDGFRB using a tyrosine
kinase inhibitor (TKI) strongly reduced tumor size in SCID-mice xenografted with NPM-ALK mouse tumor cells, and increased the survival of NPM-ALK+ transgenic mice by more than 90%. These data provide evidence for the use of FDA approved tyrosine kinase inhibitors for the effective treatment of lymphomas and encourage the development of specific clinical trials.
A new class of molecules with bifunctional properties can influence cortical neuron growth, with the potential for slowing or even reversing neuronal degeneration in Parkinson's patients.
This innovation allows to extract indispensable chemical resources out of renewable resources instead of mineral oil, the finite resource. It is a method for the degradation of terpenes by ethenolysis.
Novel chromatic phase plate designed for STED or RESOLFT fluorescence light microscopy
Tue present invention relates to the generation and use of self-standing giant porous hydrophilic nanomembranes (PHNM). Currently available nanomembranes are mainly hydrophobic, which greatly limits their application in biotechnology and life sciences. In contrast, the PHNM is made from hydrophilic polymers and is therefore ideally suited for use inaqueous media.
The non-invasive, acute or short-time preventive allergy treatment will be administered as aerosol spray, eye drops, or encapsulated for oral administration, ideally before exposure to the allergen. A complex of antibodies directed against pollen/food allergens with a cell-surface molecule prevents allergic inflammation by trappi ng the allergens on the
mucosal surface of the respi ratory tract, the eyes, or the gut.
This transfection method is characterized by molecules entering the cells through an optically induced process. By attaching the gold nanoparticles to the…
A team of scientists from Hokkaido University and the multinational electronics company TDK Corporation in Japan has developed a method to improve the…
The integrity of large structures like bridges, high-rise buildings, wind turbines, and large aircrafts is deeply related with security. Nowadays, due to the…
To grow or to specialise? To remain stationary or initiate migration? How do cells know what to do and how they should develop? The Hippo/YAP signalling…
They say that once you've learned to ride a bicycle, you never forget how to do it. But new research suggests that while learning, the brain is actively trying…
When carbon dioxide emissions from cars or power plants are absorbed by the oceans, it changes seawater chemistry and makes it more acidic, a process called…
In behavioural experiments, the scientists have studied the ability to resolve visual detail in time in three small wild passerine species: blue tit, collared…
The Lomonosov Moscow State University astronomers who created a global network of robotelescopes MASTER detected that a bright star TYC 2505-672-1 has actually…
Tropical Cyclone Emeraude formed on March 15, 2016 from a tropical low pressure area and intensified rapidly. By March 16 it was a tropical storm and a…
Scientists have many tools at their disposal for looking at preserved tissue under a microscope in incredible detail, or peering into the living body at lower…
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