Scientists at the University of Göttingen in Germany developed new and highly potent drugs with cleavable chemical linkers to develop tumor specific antibodies for selective tumor therapy (ADC). The soluble prodrugs are activated into highly cytotoxic drugs only in targeted tumor cells.
Simulations are a popular tool to study physical processes that cannot be investigated experimentally in detail. For example, scientists are challenged to…
Sophisticated micro- and nano-objects, as well as functional materials, are Martin Möller’s expertise. Within his ERC-funded project, he strives to make an…
Reproducibility does not come easily
Brown dwarfs are objects that are too large to be called planets, yet too small to be stars. Having a mass of only less than seven per cent of the mass of the…
An international team of scientists led by the Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research (AWI) have managed to open a new window…
Electron spin resonance (ESR) spectroscopy provides data about the structure and dynamics of large molecules and permits the examination of biologically-relevant systems, which play a role in the regulation of the expression of illness-related genes. However, magnetic markings must be affixed to strategically-selected points of protein structures, because most biological structures do not contain unpaired electrons.
At the University of Konstanz, a molecular structure and the corresponding process were developed, with which the incorporation of ESR markers into peptide structures are largely independent of existing amino acid residues. The incorporation of the markers can be done specifically in any protein structure. The peptide structure experiences no essential changes, which makes an examination using ESR spectroscopy possible in intracellular and in vivo fashion.
Pain is probably the most common symptom and sensation of a disease, and a big individual and socioeconomic challenge. Diagnostic tools are limited and do not result in clear mechanism-based insight into the etiology of the individual pain. PET-tracers are widely used as diagnostic and therapeutic tools in several types of cancer, besides other applications of visualization in various medical indications. However, there are so far only few reports, which utilize PET-tracer and PET-scan for the detection of pain (see references). The inventors have provided proof that an established PET-tracer for use in cancer can be also utilized for the detection of pain as a second medical application. They found this tracer to be enriched at the peripheral site of pain (see figure). The amount of tracer-enrichment strongly correlated with the measured change in pain sensitivity. On behalf of the University of Cologne and of the Witten/Herdecke University, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development and evaluation.
Epileptic seizures can take very different courses: Some of those affected smack their lips; others engage in unmotivated fumbling with their clothing; others…
Adsorption refers to the process by which molecules of a gas collect on the surface of a solid. Metal-organic frameworks are highly porous materials which are…
The level of investment in Europe is still significantly below the level of 2007, the period before the financial and economic crisis. The Juncker investment…
Neutron stars are the most extreme and fascinating objects known to exist in our universe: Such a star has a mass that is up to twice that of the sun but a…
In 2014, non-university research institutions spent approximately 12.5 billion euros on research and development in Germany.
Using genetic and morphological analyses the team revealed the genus Malayemys to comprise three instead of two species as previously thought. The researchers…
It is always a challenge for researchers to find the right approach for tackling a scientific issue. Yet sometimes people without any particular medical…
Previous studies have found that interactions around food in social media can influence adolescents’ consumption of candy and their willingness to try…
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