By decoupling cell growth and productivity of biosynthesis the new method and associated Escherichia coli strain allow for an increase in productivity by a factor two to three.
This could not only be interesting for pharma industry, e.g. by increasing the capacity of insulation production, but for biotechnological synthesis of succinic acid as well. The demand for succinic acid as a component of plastics such as polyamides or polyesters is estimated to amount to 250,000 tons per year.
The technology enables the fast and competitive production of specific ALA via biotechnological process technology. The production of aminolevulinic acid (ALA) is the first step in the biosynthesis of tetrapyrroles and porphyrines (like Chlorophyll, vitamin B12, heme). Recently ALA has attracted interest as a selective and biodegradable herbicide and insecticide. Besides ALA can be applied in the photodynamic therapy and treatment of various kinds of cancer.
Administration of ALA in the tumorous tissue leads to a porphyrin formation inside the cells. Accumulated porphyrins generate reactive oxygene species when excited by light which can lead to death of the tumorous cell. On behalf of the University of Bielefeld, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development.
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