The scientists from Tohoku University, the University of Tokyo, the National Astronomical Observatory of Japan, and the University of Tsukuba, used the Atacama…
Small and mid-size not mega cities are growing quickest and are highly vulnerable to extreme events and climate change – says a new study and paper in NATURE…
After a decade of travel in outer space to reach the comet Chury, and two years spent studying it, the Rosetta mission comes to an end this Friday. The mission…
Solid state physics offers a rich variety of intriguing phenomena, several of which are not yet fully understood. Experiments with fermionic atoms in optical…
By cascading two DOEs are optical elements (lens, axicon, phase shifter, spiral phase plate) obtained, whose optical power can be adjusted continuously by just rotating one DOE with respect to the other.
Selective Enhancement of Ligands by Exponential Enrichment (SELEX) has proven to be a powerful tool for idenfying functional oligonucleotides which bind to selected targets. Here, in an iterative process, a pool of single stranded oligonucleotides is contacted with a target structure (e.g. a protein), high-affinity oligonucleotides are then isolated, amplified and again put into contact with the target until, eventually, an ideal oligonucleotide has been obtained.
An International and a European patent application are pending. On behalf of University of Bonn, PROvendis offers licenses for commercial use as well a research collaboration with licensing option.
DNA lesions occur in all living organisms. As accumulating DNA damage poses a risk for cell survival, cells harbour sophisticated mechanisms for repairing such lesions. The kinase ATR (“ATM and Rad3 related”) is a key player in triggering the cellular response to double strand DNA breaks called “DNA Damage Response” (“DDR”) thereby enabling DNA repair and thus promoting cell survical.
As cancer cells are often characterized by defects in various DNA repair processes and/or DNA damages, intact ATR-signalling (and subsequent DNA-repair processes) is particularly crucial for the viability of such cancer cells.
In fact, blocking DDR, preferably by inhibiting ATR has become an attractive therapeutic concept.
Correspondingly, at present, two ATR inhibitors (VX-970 and AZD5738; for ref. see “Relevant Publications”) have already entered clinical studies.
However, both with the developmental risk associated with these compounds, the need for compounds displaying an improved safety-/efficacy-profile and the large number of patients, there is a huge interest in advanced ATR inhibitors.
The present invention thus relates to advanced ATR antagonists which have proven to be effective in various in cellular assays (both on its own and in combination with cisplatin). Furthermore they show a promising ADME-profile as deducted from predictive ADME modelling and an improved solulibility in relation to the aforementioned compounds.
Given the need for corrosion resistant materials and wastage, researchers from the Autonomous University of Puebla (BUAP) developed a coating that increases…
There are several different methods of producing images showing the changes in the brain associated with Alzheimer’s disease. The tau PET method reveals the…
Infosys Consulting, in partnership with HHL Leipzig Graduate School of Management, has recently published its latest white paper, Blockchain Technology and the…
The Greenland ice sheet records information about Arctic temperature and climate going back to more than 120 000 years ago. But new research reveals that the…
Again, Optris GmbH introduced a new infrared camera for the glass industry at the glasstec 2016. With its 7.9 µm filter, the thermal imager optris PI 640 G7 is…
A geomagnetic storm on January 17, 2013, provided unique observations that finally resolved a long-standing scientific problem. For decades, scientists had…
Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of…
Over the course of the 3-day conference, over 500 experts will debate the health and social challenges and opportunities associated with demographic change in…
A novel mesh generation method enables a fast, fully automatic generation of high-quality meshes even for complex geometrical structures.
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