… turns flat-pack tubes into strong building materials. Engineers at RMIT University have designed an innovative tubular structural system that can be packed flat for easier transport and pop up into strong building materials. This breakthrough is made possible by a self-locking system inspired by curved-crease origami — a technique that uses curved crease lines in paper folding. Lead researchers, Dr Jeff (Ting-Uei) Lee and Distinguished Professor Mike (Yi Min) Xie, said bamboo, which has internal structures providing natural reinforcement,…
UChicago Medicine has become the first medical center in Illinois to implant the Revi neuromodulation device, an exciting new treatment option that could offer relief for patients with urinary urgency incontinence (UUI). “I am really happy that we can offer this innovative approach to all our patients and very proud to be at the real forefront of medicine as the first in the state to have done this surgery,” said urologist Ervin Kocjancic, MD, the surgeon who performed the procedure. UUI,…
… could revolutionize EV market and energy storage. A multi-institutional research team led by Georgia Tech’s Hailong Chen has developed a new, low-cost cathode that could radically improve lithium-ion batteries (LIBs) — potentially transforming the electric vehicle (EV) market and large-scale energy storage systems. “For a long time, people have been looking for a lower-cost, more sustainable alternative to existing cathode materials. I think we’ve got one,” said Chen, an associate professor with appointments in the George W. Woodruff School of Mechanical Engineering and…
Experts from the University’s Centre for Targeted Protein Degradation (CeTPD), working with Boehringer Ingelheim scientists, have developed a breakthrough small-molecule drug, a “protein degrader”. KRAS is the most mutated gene in cancer with mutations occurring in 17%–25% of all cancers, affecting millions of patients worldwide. It plays a crucial role in tumour growth, as it is important for driving uncontrolled proliferation of tumour cells. Targeting KRAS function is a primary focus of cancer drug discovery. However, currently approved treatments can…
Proteins can re-structure themselves to create important substances. The protein ‘MIPS’ changes its internal structure when it becomes active. Its disordered active centre becomes a defined structure with special functions. The protein plays a key role in the production of inositol, which is also known as vitamin B8, and fulfils important tasks in the body. Researchers at Martin Luther University Halle-Wittenberg (MLU) and the National Hellenic Research Centre in Greece have succeeded for the first time in observing the protein…
Researchers find that all coral components—including its skeleton—contain microplastics. Researchers from Japan and Thailand investigating microplastics in coral have found that all three parts of the coral anatomy—surface mucus, tissue, and skeleton—contain microplastics. The findings were made possible thanks to a new microplastic detection technique developed by the team and applied to coral for the first time. These findings may also explain the ‘missing plastic problem’ that has puzzled scientists, where about 70% of the plastic litter that has entered…
Nanoparticle potential found for assessing kidneys. In a study published July 29 in Advanced Materials, University of Texas at Dallas researchers found that X-rays of the kidneys using gold nanoparticles as a contrast agent might be more accurate in detecting kidney disease than standard laboratory blood tests. Based on their study in mice, they also found that caution may be warranted in employing renal-clearable nanomedicines to patients with compromised kidneys. Before administering renal-clearable drugs, doctors routinely check a patient’s kidney function…
Thanks to innovations in design, control and production technology, brushless drives for pumps and fan systems work more efficiently and quietly. Users of electrical appliances and the automotive industry do benefit. Small electric motors can be found in many household appliances, tools and computers as well as in modern cars, where they drive auxiliary units such as pumps and fans. Individually, each of these motors does not consume much energy, but taken together they offer a great savings potential. The…
… for Neurosensory Therapies. Researchers from the Fraunhofer Institute for Photonic Microsystems IPMS and the Max Planck Institute for Multidisciplinary Natural Sciences (MPI-NAT) have researched optical stimulators for future cochlear implants as part of the “NeurOpto” project (funded by the Fraunhofer-Max-Planck Cooperation Program: 601001). They will present tiny OLED-on-silicon-based probes for the first time at W3+ 2024 in Jena, on September 25 and 26, 2024, at booth No. C12. What is Optogenetics? Optogenetics is a method that uses light to…
Personalized medicine with individually tailored therapies is becoming more and more a reality in cancer. This requires a precise look into the genetic material of tumors, a molecular diagnostic tumor profile. A research group from the German Network for Personalized Medicine (DNPM) has recorded the quality standards according to which genome analyses are carried out in Germany. The data is a prerequisite for integrating gene sequencing into routine care. The working group led by Professor Albrecht Stenzinger from the Medical…
Future treatment of high cholesterol gene defect. CRISPR-Cas systems, which consist of protein and RNA components, originally developed as a natural defense mechanism of bacteria to fend off intruding viruses. Over the last decade, re-engineering these so-called “gene scissors” has revolutionized genetic engineering in science and medicine. The tools can be programmed to find a specific location in our DNA and edit the genetic information in a precise manner. For example, a disease-causing mutation in the DNA can be reverted…
In the treatment of cancer patients, irradiation can be adapted anew each day to the position of the tumour and conditions in the body. Researchers at the Paul Scherrer Institute PSI have now, for the first time, integrated such a workflow into everyday clinical practice in proton therapy – an important step in the individualisation of therapy. The study appeared yesterday in the scientific journal Physics in Medicine and Biology. Every day, our body is a little bit different. The…
Lasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions. In a new study, published in Nature Chemical Biology, researchers have constructed and tested models for how these peptides are made and demonstrated how this information might be used to advance lasso peptide-based drugs into the clinic. “Lasso peptides are interesting because they are basically linear molecules that have been tied into a slip knot-like shape,” said Susanna Barrett,…
…promote the transformation of prostate cancer cells into treatment-resistant cells. There is a challenge related to prostate and many other cancers that cancer cells form resistance to treatments as the disease progresses. However, these resistance mechanisms are not yet fully understood. A new study by the University of Eastern Finland found that inflammation-promoting immune cells, M1 macrophages, can transform cancer cells into stem-like cells and thus immune to treatment. The results were published in OncoImmunology journal. The study examined the…
More efficient isotope separation in sight. The lightest of all elements, hydrogen, is in great demand due to its promising role as a sustainable resource in the energy transition. A team from Leipzig University and TU Dresden, as part of the Hydrogen Isotopes 1,2,3H Research Training Group, has made an important breakthrough in the efficient and cost-effective provision of isotopes. These are the three forms in which hydrogen occurs in nature – as protium, deuterium or tritium. The international team…
Although Mars is currently a cold, dry planet, geological evidence suggests that liquid water existed there around 3 to 4 billion years ago. Where there is water, there is usually life. In their quest to answer the burning question about life on Mars, researchers at Tohoku University created a detailed model of organic matter production in the ancient Martian atmosphere. Organic matter refers to the remains of living things such as plants and animals, or the byproduct of certain chemical…
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