Vaccination strategy
The present invention is based on the discovery of a so far unrecognized anatomic compartment within liver tissue that is formed by myeloid cells. These intrahepatic myeloid cell aggregates support local T cell expansion (iMATE) presumably by generating a cocoon-like structure that prevents hepatic regulatory cues to affect T cell proliferation within iMATEs.
This new observation can be exploited for the use of a vaccination strategy.
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