3D-TAM – A 3D-Printed Biomimetic Tumour Angiogenesis Model
The present invention describes a novel 3D-bioprinting process for the production of a three-dimensional, biomimetic tumour angiogenesis model (3D-TAM). In a first step, a supply channel covered by an endothelial cell layer is generated using the 3D-bioprinting process and in a second step, tumour cells are embedded into a surrounding hydrogel-matrix cell-suspension. Then, angiogenesis will start from the supply channel towards the tumour cells (which release angiogenic factors) leading to a vascularized and perfusable tumour.
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