Peptides for inhibition of the HPV-E6 oncoprotein
Human papilloma viruses (HPVs) are associated
with various tumors in humans. Specific HPV types (most commonly HPV16) cause cervical cancer, Here, the continuous expression of the viral E6 and E7 oncogenes is essential to maintain the tumorigenic phenotype. One major function of the viral E6 protein is to mediate degradation of the tumorsuppressor protein p53. By blocking apoptosis, this activity is crucial both for tumor formation and for the therapeutic resistance of HPV-positive cancer cells. The peptides identified by our inventors block the intracellular activity of the HPV16 E6 protein and thus increase sensitivity of tumor cells towards apoptosis. This effect is highly specific for HPV16- containing tumor cells.
Further Information: PDF
DKFZ (German Cancer Research Center, Deutsches Krebsforschungszentrum)
Phone: +49-6221-42 2955
Contact
Dr. Ruth Herzog
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Sea slugs inspire highly stretchable biomedical sensor
USC Viterbi School of Engineering researcher Hangbo Zhao presents findings on highly stretchable and customizable microneedles for application in fields including neuroscience, tissue engineering, and wearable bioelectronics. The revolution in…
Twisting and binding matter waves with photons in a cavity
Precisely measuring the energy states of individual atoms has been a historical challenge for physicists due to atomic recoil. When an atom interacts with a photon, the atom “recoils” in…
Nanotubes, nanoparticles, and antibodies detect tiny amounts of fentanyl
New sensor is six orders of magnitude more sensitive than the next best thing. A research team at Pitt led by Alexander Star, a chemistry professor in the Kenneth P. Dietrich…
