Novel Method producing/selecting and humanizing Antibodies
Monoclonal antibodies specifically bind to target cells or proteins and are therefore used as cancer diagnostics as well as therapeutics. The production of antibodies is different and there are also distinct antibody libraries existing to select the most effective antibodies.
We here describe a new method for producing a highly diverse antibody library, where pro-teins/antibodies can be selected for specific ap-plications. A large and, compared from cell to cell, highly uniform number of antibodies is covalently attached to the surface of a eukaryotic cell. Using this technology, specific antibodies can be se-lected together with the presenting cell out of a high number of cells in a comparatively easy way. The technology can also be used humanizing a hybridoma cell line by enabling the homologous recombination of the constant domains of human immunoglobulins with the respective gene.
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DKFZ (German Cancer Research Center, Deutsches Krebsforschungszentrum)
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