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RC HydroCat – Hydrogenation catalyst for selective asymmetric reaction of heteroaromatics
Scientists at the Westfälische Wilhelms-Universität Münster developed a catalyst system for selective and stereospecific hydrogenation of heteroaromatic compounds. The catalyst comprises a ruthenium complex and chiral N-heterocyclic carbene ligands. The RC Hydrocat is suitable for asymmetric hydrogenation of the heterocyclic ring, whereby a plurality of substances are efficiently, selectively and directly accessible.
Commercial application: Saturated and partially saturated heterocycles represent an important structural element in many biologically active compounds. RC Hydrocat now provides a hydrogenation tool for laboratory and pilot plant, especially for tetrabenzannelated substances to transfer to other heteroaromatic valuable substances. Despite the mild reaction conditions RC Hydrocat results in high yields with good selectivity. The hydrogenation has been shown using the example in O-, S-and NR- heterocycles, such as benzofurans, benzothiophene, Phenyl- furanes Indolizine and with a number of derivatives thereof.
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