Optical Tomography (OT) and PET combination for dual-modality imaging
DKFZ developed an optical imaging detector for fluorescence and bioluminescence in small animal imaging, which is compatible for positron electron tomography (PET).
Compatibility of light detection with PET has been accomplished by developing an optical detector that consists of a 25 mm x 100 mm photon sensor (liquid cooled) for light detection, a microlens array for field-of-view definition, a septum masks for cross-talk suppression, and a transferable filter for wavelength selection. The instrument has been evaluated regarding ist optical performance and was successfully used in a number of preclinical studies such as simultaneous positron (18F-FDG, 68Ga-RGD) – bioluminescence (PC-3-hVEGF-Luc) imaging of reporter gene expression and receptor targeting in mice or simultaneous imaging of fluorescent XenoLight-RediJect-2-DG-750 and radio-labeled FDG probes.
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