

Recent findings in animal models underline the potential role of the acid sphingomyelinase (aSMase) as an important drug target in inflammatory lung diseases like acute lung injury (ALI) – the main cause of death in intensive care units -, acute respiratory distress syndrome (ARDS), lung emphysema, and cystic fibrosis.<br><br>
The invention offers simple geminal bisphosphonates with a prolonged carbon chain as potent and selective inhibitors of the acid sphingomyelinase. The compounds can be synthesized in a one-step or two-step procedure and show clear inhibition of cell death in vitro. First ex vivo data in rats show a reduction of platelet activating factor (PAF) – induced pulmonary edema in the presence of the bisphosphonates by at least 50 percent. Aerosols of bisphosphonates may be possible applicants for the treatment of pulmonary diseases. <br> Besides their use in inflammatory lung diseases the bisphosphonates with prolonged carbon chain may be used as a treatment option for cystic fibrosis and atherosclerosis. <br><br> Besides their use in inflammatory lung diseases the novel bisphosphonates with prolonged carbon chain may be used as treatment option for cystic fibrosis and atherosclerosis.<br><br> <b>Benefits:</b><br> <ul> <li>Neutral sphingomyelinase is not influenced</li> <li>First ex-vivo data in a PAF-induced edema rat model showed clear edema reduction by 50percent</li> <li>Inhibition of dexamethasone induced apoptosis was proven <em>in vitro</em></li> <li>Substances can easily be synthesized in a one-step or two-step procedure</li> <li>Prolongation from 6 to 8 C-atoms shows 40times higher inhibition rate</li> </ul> <p><strong>IP Rights</strong><br> EP Application (08/2009).<br> PCT Application (08/2010). <br> A PCT application was filed in August 2010.<br> <br> <strong>Patent Owner</strong><br> Humboldt-Universität zu Berlin<br> Rheinisch-Westfälische<br> Technische Hochschule Aachen (RWTH)<br><br> <b>Find the technology offer and contact details here: <a href=”http://www.ipal.de/technologieangebote/09061″ target=”_blank”>http://www.ipal.de/technologieangebote/09061</a></b>
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