Targeted retrieval of recombinase activity by trans-splicing
The Cre/lox system constitutes a method for the site-directed recombination of nucleic acids, in which the enzyme Cre-recombinase achieves recombination of DNA at specific target sequences, the so-called loxP-sites. In this process the activity of the Cre-recombinase is dependent on the control of a cell-specific promotor. This method presently is applied in great variety for systematic mutagenesis, for example for the generation of gene-knockouts in mice-models.
Further Information: PDF
IMG Innovations-Management GmbH
Phone: +49 (0)631/31668-50
Contact
Dr. Klaus Kobek
Media Contact
All latest news from the category: Technology Offerings
Newest articles
For microscopic organisms, ocean currents act as ‘expressway’ to deeper depths
New research shows how tiny plant-like organisms hitch a ride on ocean currents to reach darker and deeper depths, where they impact carbon cycling and microbial dynamics in the subtropical…
FDmiX: Fast, robust series production of nanoparticles
Nucleic acid-based medications such as mRNA vaccines are opening up new therapeutic approaches. These active ingredients must be enclosed inside nanoparticles to ensure that they get to where they are…
Sensor measures oxygen content of breath
Oxygen saturation in the blood that is either too low or too high can cause physical harm or even death. This is why patients’ oxygen concentraions are monitored continuously in…