Allosteric activators and inhibitors of proteinkinases of the AGC- and the Aurora-family
Another new approach to influence protein kinases which is also part of this invention is the allosteric regulation of such enzymes.
A hydrophobe binding site on the surface of some protein kinases of the AGC-family was identified by analyzing their crystal structure. The invention includes some new classes of small molecule compounds which bind to and by allosteric effect influence the acitivity of protein kinases. The inventors were able to inhibit the kinase activity as well as to cause an activation of the kinase. Both were examined with several different protein kinase assays.
Further Information: PDF
Universität des Saarlandes Wissens- und Technologietransfer GmbH PatentVerwertungsAgentur der saarländischen Hochschulen
Phone: +49 (0)681/302-6340
Contact
Dipl. Chem. Dagmar Vössing, Dipl.-Kfm. Axel Koch MBA, Dipl. Ing. Gerd Schneider
Media Contact
All latest news from the category: Technology Offerings
Newest articles
Recovering phosphorus from sewage sludge ash
Chemical and heat treatment of sewage sludge can recover phosphorus in a process that could help address the problem of diminishing supplies of phosphorus ores. Valuable supplies of phosphorus could…
Efficient, sustainable and cost-effective hybrid energy storage system for modern power grids
EU project HyFlow: Over three years of research, the consortium of the EU project HyFlow has successfully developed a highly efficient, sustainable, and cost-effective hybrid energy storage system (HESS) that…
After 25 years, researchers uncover genetic cause of rare neurological disease
Some families call it a trial of faith. Others just call it a curse. The progressive neurological disease known as spinocerebellar ataxia 4 (SCA4) is a rare condition, but its…
