Technology Offerings

Targeted Retrieval of Recombinase Activity via Trans-Splicing

The Cre/lox system constitutes a method for the site-directed recombination of nucleic acids, in which the enzyme Cre-recombinase achieves recombination of DNA at specific target sequences, the so-called loxP-sites. In this process the activity of the Cre-recombinase is dependent on the control of a cell-specific promotor. This method presently is applied in great variety for systematic mutagenesis, for example for the generation of gene-knockouts in mice-models.

Further Information: PDF

IMG Innovations-Management GmbH
Phone: +49 (0)631/31668-50

Contact
Dr. Klaus Kobek

Comments (0)

Write a comment