Monoclonal antibody: Mouse anti-human / anti-rat beta-arrestin1,2
Scientists at the Georg-August-University produced different monoclonal antibodies directed against beta-arrestin1 and beta-arrestin2 (one reacts specifically with beta-arrestin1 but not beta-arrestin2, the other one with both of them). Arrestins are cytosolic proteins that are involved in G protein-coupled receptor (GPCR) desensitization. Arrestin binding to activated GPCRs phosphorylation dependent and once bound, uncouple the GPCR from the associated heterotrimeric G proteins. There are currently known 4 mammalian isoforms, beta-arrestin1 (arrestin2), beta-arrestin2 (Arrestin3), visual arrestin (Arrestin1), and cone arrestin. The beta-isoforms are ubiquitously expressed and known to interact with acetylcholine and adrenergic receptors.
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