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SMA therapy approach - Down-regulation of NCALD in spinal muscular atrophy and diseases with a disturbed calcium homeostasis


Spinal muscular atrophy (SMA) is an autosomal recessive disorder based on the loss of the survival motor neuron 1 (SMN1) genes. The severity of the disease is inversely correlated with the copy number of the main disease modifying gene SMN2. In rare cases, siblings of SMA patients do not show SMA, although they carry exactly the same SMN1 and SMN2 gene status as their SMA affected relatives. So other genetic factors are able to fully protect homozygously SMN1-deleted individuals from developing SMA. The inventors found that this phenomenon might be caused by the overexpression of plastin 3, an actin-bundling protein, and/or low expression levels of the calcium sensing protein neurocalcin delta (NCALD). In vitro and in vivo studies show that inhibitors of neurocalcin delta (NCALD) are suitable for treating and preventing such disorders in a patient. Said inhibitors are, likewise, effective tools for in vitro neuronal differentiation and maturation, and restoration of impaired endocytosis.

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