Scientists from Goethe University of Frankfurt am Main have identified serum biomarkers that differentiate patients with hepatocellular carcinoma (HCC) from those with liver cirrhosis. The identified sphingolipid metabolites C16-ceramide and sphingosine-1-phosphate (S1P) provide an extraordinary high diagnostic accuracy (AUC value > 0.98). Current HCC tests measure levels of alpha-fetoprotein (AFP) which show a significantly lower diagnostic performance.
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