The major clinical challenge in treating NPM-ALK+ anaplastic large cell lymphomas (ALCL) is its high rate of relapse. Researchers of the Medical University of Vienna identified high expression of PDGFRß in the NPMALK induced ALCL. Pharmaceutical targeting of PDGFRB using a tyrosine kinase inhibitor (TKI) strongly reduced tumor size in SCID-mice xenografted with NPM-ALK mouse tumor cells, and increased the survival of NPM-ALK+ transgenic mice by more than 90%. These data provide evidence for the use of FDA approved tyrosine kinase inhibitors for the effective treatment of lymphomas and encourage the development of specific clinical trials.
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