Scientists of the University of Duisburg-Essen developed a platform, which facilitates the detection of deletions and insertions as well as point mutations in target genes from a variety of sources against a huge background of wild type alleles, making a clear Yes or No output possible and thereby simplifying therapeutic decisions. Neither expensive and complicated equipment nor specialized personnel is needed. The assay is robust and applicable in all laboratories equipped with an RT-PCR machine. It can easily be established for point of care (PoC) purposes. This sensitive technology now enables clinicians to be independent of the scarce resource tissue biopsy. By using blood (ctDNA, cfDNA or CTC) it opens new non-invasive possibilities for monitoring the mutation status of patients before and during treatment as well as to detect disease relapse early. A European and a US patent have already been granted, other applications are pending.
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