This invention enables an easy and economical way for the stratification of patients (e.g. for treatment with tyrosine-kinase-inhibitors) with a state-of-the-art sensitivity, which might be even be more sensitive than mutation detection by next-generation-sequencing technologies. In addition this detection technology is based on the established and worldwide accessible RT-PCR-platform. It can even be used - in combination with suitable enrichment strategies - for the non-invasive analysis of CTCs or free DNA from plasma/serum samples to facilitate continuous monitoring of treatment response. Currently, the inventors are establishing strategies for detecting a panel of the most common oncogenic mutations with similar impressive sensitivities.
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Dipl.-Ing. Alfred Schillert
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