Domain-exchanged complete antibody composed of the Fc fragment and variable domains where CH1 and CL domains have been exchanged for a pair of CH3 domains. Modular immunoglobulins composed of Fab-like fragment with HerceptinVL and VH region and CH3 domains and an unmodified Fc fragment are described. Novel is an increased binding to FcR³III, which leads to potentiated T-cell activation upon binding to a Her2-positive cell line
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