Colorectal cancer (CRC) is the third most frequently occurring cancer in both sexes. It ranks second in developed countries. Tumor growth beyond the critical two to three millimeter diameter and metastasis require angiogenesis. Therefore, in later tumor stages, antiangiogenic treatment offers a strategy that has been shown in clinic to improve outcomes in patients with advanced or metastatic colorectal cancer (mCRC). Today, several antiangiogenic drugs for tumor therapeutic application have been approved, e.g. Bevacizumab (Avastin®), Cetuximab (Erbitux®) or Panitumumab (Vectibix®). Nevertheless, 20% of the patients do not respond and are resistant to antiangiogenic therapy. This invention provides a method which allows to further improve the efficacy of antiangiogenic therapy in colorectal cancer (CRC). This is achieved by detection and exclusion of patients, which are in a therapy resistant tumor stage.
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