Biotechnological expression of highly active proteins or small chemical compounds of pharmaceutical relevance is often difficult. Many proteins or molecules of interest (POIs/MOIs) have cytotoxic side effects and interfere with the hosts metabolism. The invention provides a versatile tool - based on a low-temperature inducible protein accumulation system (lt-degron) - and methods to generate so-called phenotypes on demand for the production of POIs/MOIs in a spatial and time-dependent manner ensuring proper posttranslational modifications. For the first time, it has been adopted to multicellular organisms like insects and intact plants in vivo.
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