Enantiomerically pure N-acyl-a-aminonitriles gained these days interest in the pharmaceutical industry since a range of recently developed pharmaceuticals are based on this product class. Prominent examples are Vildagliptin®, Saxagliptin® or NVP-DPP-728, which are active pharmaceutical ingredients against diabetes type II and at least two of them are successful already on the market. The described technology enables a safe, fast and competitive chemical production of specific N-acyl-a-aminonitriles or N-sulfonyl-a-aminonitriles, serving as intermediates for the synthesis of, e.g., Vildagliptin®. On behalf of the Bielefeld University, PROvendis offers access to rights for commercial use as well as the opportunity for further co-development.
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